Homo sapiens Gene: E2F3 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-64143.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | E2F3 | ||||||||||||||||||||||
Gene Name | E2F transcription factor 3 | ||||||||||||||||||||||
Synonyms | E2F-3 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000112242 | ||||||||||||||||||||||
Encoded Proteins |
E2F transcription factor 3
E2F transcription factor 3
E2F transcription factor 3
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a member of a small family of transcriptional factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate expression of cell-cycle genes. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 6:20401906-20493715 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | p22.3 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Association of licensing factors with the pre-replicative complex pathway
CDC6 association with the ORC:origin complex pathway
Assembly of the pre-replicative complex pathway
Cyclin D associated events in G1 pathway
G2 Phase pathway
Pre-NOTCH Transcription and Translation pathway
DNA Replication pathway
G1 Phase pathway
Cellular responses to stress pathway
Oncogene Induced Senescence pathway
Pre-NOTCH Expression and Processing pathway
Mitotic G1-G1/S phases pathway
DNA Replication Pre-Initiation pathway
Signal Transduction pathway
Cell Cycle pathway
Cellular Senescence pathway
Signaling by NOTCH pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
Regulation of DNA replication pathway
Oxidative Stress Induced Senescence pathway
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KEGG |
Non-small cell lung cancer pathway
Cell cycle pathway
Melanoma pathway
Bladder cancer pathway
Glioma pathway
Small cell lung cancer pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Pancreatic cancer pathway
Pathways in cancer pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Validated targets of C-MYC transcriptional activation
E2F transcription factor network
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.269408 | ||||||||||||||||||||||
RefSeq | NM_001243076 NM_001949 XM_005248865 XM_005248866 XM_005248868 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS4545 CCDS58999 | ||||||||||||||||||||||
HPRD | 02693 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||