Version 5.4
Homo sapiens Gene: CSHL1
Summary
InnateDB Gene IDBG-64181.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSHL1
Gene Name chorionic somatomammotropin hormone-like 1
Synonyms CS-5; CSHP1; CSL; hCS-L
Species Homo sapiens
Ensembl Gene ENSG00000204414
Encoded Proteins
IDBP-63845
chorionic somatomammotropin hormone-like 1
IDBP-64183
chorionic somatomammotropin hormone-like 1
IDBP-64185
chorionic somatomammotropin hormone-like 1
IDBP-244871
chorionic somatomammotropin hormone-like 1
IDBP-383355
chorionic somatomammotropin hormone-like 1
IDBP-383381
chorionic somatomammotropin hormone-like 1
IDBP-584061
chorionic somatomammotropin hormone-like 1
IDBP-810921
chorionic somatomammotropin hormone-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. This particular family member is expressed in placental villi, although it was originally thought to be a pseudogene. In fact, alternative splicing suggests that the majority of the transcripts would be unable to express a secreted protein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:63909597-63918838
Strand Reverse strand
Band q23.3
Transcripts
ENST00000259003 ENSP00000259003
ENST00000309894 ENSP00000309524
ENST00000346606 ENSP00000316360
ENST00000392824 ENSP00000376569
ENST00000438387 ENSP00000402632
ENST00000450719 ENSP00000413501
ENST00000561003 ENSP00000452900
ENST00000558099
ENST00000560999
ENST00000558609
ENST00000611417 ENSP00000483369
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0046872 metal ion binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001318 NM_022579 NM_022580 NM_022581
HUGO
OMIM
CCDS CCDS11652 CCDS42370 CCDS45759
HPRD 04623
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca