Version 5.4
Bos taurus Gene: KIT
Summary
InnateDB Gene IDBG-642326.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIT
Gene Name Mast/stem cell growth factor receptor Kit
Synonyms c-kit
Species Bos taurus
Ensembl Gene ENSBTAG00000002699
Encoded Proteins
IDBP-694793
Mast/stem cell growth factor receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157404:
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:71796318-71917431
Strand Forward strand
Band
Transcripts
ENSBTAT00000003498 ENSBTAP00000003498
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0002020 protease binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0005020 stem cell factor receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019955 cytokine binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0001541 ovarian follicle development
GO:0002318 myeloid progenitor cell differentiation
GO:0002320 lymphoid progenitor cell differentiation
GO:0002327 immature B cell differentiation
GO:0002371 dendritic cell cytokine production
GO:0002551 mast cell chemotaxis
GO:0002573 myeloid leukocyte differentiation
GO:0006468 protein phosphorylation
GO:0006687 glycosphingolipid metabolic process
GO:0006954 inflammatory response
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0008584 male gonad development
GO:0009314 response to radiation
GO:0010628 positive regulation of gene expression
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0023014 signal transduction by phosphorylation
GO:0030032 lamellipodium assembly
GO:0030097 hemopoiesis
GO:0030217 T cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030318 melanocyte differentiation
GO:0031532 actin cytoskeleton reorganization
GO:0032762 mast cell cytokine production
GO:0035162 embryonic hemopoiesis
GO:0035234 ectopic germ cell programmed cell death
GO:0035556 intracellular signal transduction
GO:0035855 megakaryocyte development
GO:0038093 Fc receptor signaling pathway
GO:0038109 Kit signaling pathway
GO:0038162 erythropoietin-mediated signaling pathway
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043069 negative regulation of programmed cell death
GO:0043303 mast cell degranulation
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043473 pigmentation
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046777 protein autophosphorylation
GO:0048066 developmental pigmentation
GO:0048070 regulation of developmental pigmentation
GO:0048565 digestive tract development
GO:0048863 stem cell differentiation
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060326 cell chemotaxis
GO:0060374 mast cell differentiation
GO:0097067 cellular response to thyroid hormone stimulus
GO:0097324 melanocyte migration
GO:0097326 melanocyte adhesion
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042629 mast cell granule
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000157404
View Gene Order
ENSMUSG00000005672
View Gene Order
Pathways
NETPATH
REACTOME
REACT_217956
DAP12 interactions pathway
REACT_208036
Signaling by EGFR pathway
REACT_222082
GAB1 signalosome pathway
REACT_204365
Signaling by PDGF pathway
REACT_216183
Signaling by ERBB4 pathway
REACT_202837
Signaling by FGFR pathway
REACT_215558
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_219416
PI3K events in ERBB2 signaling pathway
REACT_213138
Immune System pathway
REACT_215895
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_205435
Signaling by the B Cell Receptor (BCR) pathway
REACT_218958
Signaling by ERBB2 pathway
REACT_214353
Signal Transduction pathway
REACT_221368
Signaling by EGFR in Cancer pathway
REACT_204467
PI-3K cascade pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_223238
Regulation of KIT signaling pathway
REACT_222492
PI3K events in ERBB4 signaling pathway
REACT_206613
Downstream signaling of activated FGFR pathway
REACT_207066
Signalling by NGF pathway
REACT_221870
PI3K/AKT Signaling in Cancer pathway
REACT_224097
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_214469
Adaptive Immune System pathway
REACT_212750
Downstream signal transduction pathway
REACT_208171
PIP3 activates AKT signaling pathway
REACT_204114
Signaling by SCF-KIT pathway
REACT_216714
Innate Immune System pathway
REACT_225332
PI3K/AKT activation pathway
REACT_214988
DAP12 signaling pathway
REACT_207087
Disease pathway
REACT_203736
Signaling by FGFR in disease pathway
REACT_225357
Fc epsilon receptor (FCERI) signaling pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111225
Regulation of KIT signaling pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_239142
Innate Immune System pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_189085
Disease pathway
REACT_227425
Regulation of KIT signaling pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_242976
Signaling by EGFR pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_206286
GAB1 signalosome pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa05221
Acute myeloid leukemia pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04916
Melanogenesis pathway
hsa04144
Endocytosis pathway
hsa05200
Pathways in cancer pathway
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu05221
Acute myeloid leukemia pathway
mmu04640
Hematopoietic cell lineage pathway
mmu04916
Melanogenesis pathway
mmu04144
Endocytosis pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
cmyb_pathway
C-MYB transcription factor network
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt P43481
TrEMBL Q9BDG2 Q9MYN0
UniProt Splice Variant
Entrez Gene 280832
UniGene Bt.91791
RefSeq NM_001166484 XM_005207937 XM_005207938 XM_005207939
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF263826 AF263827 AJ305313 D16680
GenPept AAF73441 AAF73442 BAA04084 CAC36140
RNA Seq Atlas 280832

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca