Version 5.4
| Homo sapiens Gene: IL18RAP | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-64252.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | IL18RAP | ||||||||||||||||||
| Gene Name | interleukin 18 receptor accessory protein | ||||||||||||||||||
| Synonyms | ACPL; CD218b; CDw218b; IL-18R-beta; IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RB | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000115607 | ||||||||||||||||||
| Encoded Proteins |
interleukin 18 receptor accessory protein
interleukin 18 receptor accessory protein
interleukin 18 receptor accessory protein
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. [provided by RefSeq, Jul 2008] The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn\'s disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 2:102418689-102452565 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | q12.1 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG |
Cytokine-cytokine receptor interaction pathway
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| INOH | |||||||||||||||||||
| PID NCI |
IL12-mediated signaling events
IL12 signaling mediated by STAT4
IL23-mediated signaling events
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| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | Q3KPE8 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 8807 | ||||||||||||||||||
| UniGene | Hs.158315 | ||||||||||||||||||
| RefSeq | NM_003853 XM_005264034 | ||||||||||||||||||
| HUGO | HGNC:5989 | ||||||||||||||||||
| OMIM | 604509 | ||||||||||||||||||
| CCDS | CCDS2061 | ||||||||||||||||||
| HPRD | 05147 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC007248 AC007278 BC106764 | ||||||||||||||||||
| GenPept | AAI06765 | ||||||||||||||||||
| RNA Seq Atlas | 8807 | ||||||||||||||||||