Homo sapiens Gene: KCNE3
Summary
InnateDB Gene IDBG-64310.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNE3
Gene Name potassium voltage-gated channel, Isk-related family, member 3
Synonyms HOKPP; HYPP; MiRP2;
Species Homo sapiens
Ensembl Gene ENSG00000175538
Encoded Proteins
potassium voltage-gated channel, Isk-related family, member 3
potassium voltage-gated channel, Isk-related family, member 3
potassium voltage-gated channel, Isk-related family, member 3
potassium voltage-gated channel, Isk-related family, member 3
potassium voltage-gated channel, Isk-related family, member 3
potassium voltage-gated channel, Isk-related family, member 3
Protein Structure
Entrez Gene
Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:74454841-74467729
Strand Reverse strand
Band q13.4
Transcripts
ENST00000310128 ENSP00000310557
ENST00000525550 ENSP00000433633
ENST00000532569 ENSP00000431739
ENST00000531854 ENSP00000433697
ENST00000529425 ENSP00000434890
ENST00000526855 ENSP00000435539
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005249 voltage-gated potassium channel activity
GO:0015459 potassium channel regulator activity
Biological Process
GO:0006811 ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0043266 regulation of potassium ion transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Protein digestion and absorption pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y6H6
TrEMBL E9PJV9 E9PN03 Q2N1I1 Q6IAE6
UniProt Splice Variant
Entrez Gene 10008
UniGene Hs.523899
RefSeq NM_005472
HUGO HGNC:6243
OMIM 604433
CCDS CCDS8232
HPRD 07256
IMGT
EMBL AF076531 AF302494 AK311876 AP001372 BC032235 BC110612 BC113743 CH471076 CR457209 CR936625 DQ192291 DQ192292 DQ784805
GenPept AAD28089 AAG16255 AAI10613 AAI13744 ABB00304 ABB00305 ABQ01240 BAG34817 CAG33490 CAI56768 EAW74938
ImmGen KCNE3 (murine)
RNA Seq Atlas 10008