Version 5.4
Homo sapiens Gene: NR1H2
Summary
InnateDB Gene IDBG-64316.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NR1H2
Gene Name nuclear receptor subfamily 1, group H, member 2
Synonyms LXR-b; LXRB; NER; NER-I; RIP15; UNR
Species Homo sapiens
Ensembl Gene ENSG00000131408
Encoded Proteins
IDBP-64320
nuclear receptor subfamily 1, group H, member 2
IDBP-383780
nuclear receptor subfamily 1, group H, member 2
IDBP-765374
IDBP-764419
IDBP-766281
IDBP-765988
IDBP-763030
IDBP-760426
IDBP-764112
IDBP-763046
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:50329653-50382982
Strand Forward strand
Band q13.33
Transcripts
ENST00000253727 ENSP00000253727
ENST00000411902 ENSP00000396151
ENST00000600978
ENST00000593532 ENSP00000472271
ENST00000600355 ENSP00000473099
ENST00000593926 ENSP00000471194
ENST00000597085
ENST00000597157 ENSP00000469778
ENST00000598168 ENSP00000471294
ENST00000597130 ENSP00000472138
ENST00000595730
ENST00000597790 ENSP00000470518
ENST00000599105 ENSP00000472526
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 86 [view]
Protein-Protein 86 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001133 sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0034191 apolipoprotein A-I receptor binding
GO:0043565 sequence-specific DNA binding
GO:0046965 retinoid X receptor binding
GO:0051117 ATPase binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010875 positive regulation of cholesterol efflux
GO:0010887 negative regulation of cholesterol storage
GO:0030522 intracellular receptor signaling pathway
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032369 negative regulation of lipid transport
GO:0032376 positive regulation of cholesterol transport
GO:0043401 steroid hormone mediated signaling pathway
GO:0044255 cellular lipid metabolic process
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048384 retinoic acid receptor signaling pathway
GO:0048550 negative regulation of pinocytosis
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:2000188 regulation of cholesterol homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000060601
View Gene Order
ENSBTAG00000003264
Not yet available
Pathways
NETPATH
REACTOME
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.432976 Hs.718380
RefSeq NM_001256647 NM_007121
HUGO
OMIM
CCDS CCDS42593 CCDS58673
HPRD 02660
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca