InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: POLD3

Summary

InnateDB Gene

IDBG-64335.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLD3

Gene Name

polymerase (DNA-directed), delta 3, accessory subunit

Synonyms

P66; P68; PPP1R128

Species

Homo sapiens

Ensembl Gene

ENSG00000077514

Encoded Proteins

IDBP-64337

polymerase (DNA-directed), delta 3, accessory subunit

IDBP-602351

polymerase (DNA-directed), delta 3, accessory subunit

IDBP-603704

polymerase (DNA-directed), delta 3, accessory subunit

IDBP-596910

polymerase (DNA-directed), delta 3, accessory subunit

IDBP-587391

polymerase (DNA-directed), delta 3, accessory subunit

IDBP-587277

polymerase (DNA-directed), delta 3, accessory subunit

IDBP-584834

polymerase (DNA-directed), delta 3, accessory subunit

IDBP-588810

polymerase (DNA-directed), delta 3, accessory subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3\' to 5\' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:74493851-74669117

Strand

Forward strand

Band

q13.4

Transcripts

ENST00000263681	ENSP00000263681
ENST00000528481	ENSP00000431239
ENST00000532784
ENST00000527458	ENSP00000432951
ENST00000532497	ENSP00000436018
ENST00000530511	ENSP00000432233
ENST00000531615	ENSP00000437231
ENST00000524752	ENSP00000432969
ENST00000530163
ENST00000532954	ENSP00000436781

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0000722	telomere maintenance via recombination
GO:0000723	telomere maintenance
GO:0000731	DNA synthesis involved in DNA repair
GO:0006260	DNA replication
GO:0006261	DNA-dependent DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006284	base-excision repair
GO:0006289	nucleotide-excision repair
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0006298	mismatch repair
GO:0032201	telomere maintenance via semi-conservative replication