Version 5.4
Homo sapiens Gene: CD79B
Summary
InnateDB Gene IDBG-64384.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD79B
Gene Name CD79b molecule, immunoglobulin-associated beta
Synonyms AGM6; B29; IGB
Species Homo sapiens
Ensembl Gene ENSG00000007312
Encoded Proteins
IDBP-64386
CD79b molecule, immunoglobulin-associated beta
IDBP-64388
CD79b molecule, immunoglobulin-associated beta
IDBP-244934
CD79b molecule, immunoglobulin-associated beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:63928740-63932354
Strand Reverse strand
Band q23.3
Transcripts
ENST00000006750 ENSP00000006750
ENST00000349817 ENSP00000245862
ENST00000392795 ENSP00000376544
ENST00000559358
ENST00000558969
ENST00000583260
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 8 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0019815 B cell receptor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040592
View Gene Order
ENSBTAG00000044204
Not yet available
Pathways
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
KEGG
hsa04662
B cell receptor signaling pathway pathway
INOH
INOH website
B cell receptor signaling pathway
PID NCI
bcr_5pathway
BCR signaling pathway
Cross-References
SwissProt P40259
TrEMBL
UniProt Splice Variant
Entrez Gene 974
UniGene Hs.89575
RefSeq NM_000626 NM_001039933 NM_021602
HUGO HGNC:1699
OMIM 147245
CCDS CCDS11655 CCDS11656 CCDS42372
HPRD
IMGT
EMBL AK222954 AK223210 BC002975 BC032651 L27587 M80461 M89957 S52229 S79249 X83539
GenPept AAA58387 AAA64459 AAA72424 AAB24822 AAC60654 AAH02975 AAH32651 BAD96674 BAD96930 CAA58522
RNA Seq Atlas 974

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca