InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ADCYAP1

Summary

InnateDB Gene

IDBG-644139.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADCYAP1

Gene Name

pituitary adenylate cyclase-activating polypeptide precursor

Synonyms

PACAP

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020650

Encoded Proteins

IDBP-696753

pituitary adenylate cyclase-activating polypeptide

IDBP-696755

pituitary adenylate cyclase-activating polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141433:
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 24:36114521-36121103

Strand

Forward strand

Band

Transcripts

ENSBTAT00000027516	ENSBTAP00000027516
ENSBTAT00000047551	ENSBTAP00000044751

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005184	neuropeptide hormone activity
GO:0016521	pituitary adenylate cyclase activating polypeptide activity
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0007218	neuropeptide signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010628	positive regulation of gene expression
GO:0019933	cAMP-mediated signaling
GO:0031175	neuron projection development
GO:0032854	positive regulation of Rap GTPase activity
GO:0032880	regulation of protein localization
GO:0045786	negative regulation of cell cycle
GO:0045860	positive regulation of protein kinase activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070374	positive regulation of ERK1 and ERK2 cascade