Version 5.4
| Bos taurus Gene: MAP2K2 | |||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||
| InnateDB Gene | IDBG-644312.3 | ||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
| Gene Symbol | MAP2K2 | ||||||||||||||||||||||||||
| Gene Name | dual specificity mitogen-activated protein kinase kinase 2 | ||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000024450 | ||||||||||||||||||||||||||
| Encoded Proteins |
dual specificity mitogen-activated protein kinase kinase 2
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| Protein Structure | |||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||
| Summary |
[Homo sapiens] MAP2K2 (MEK2)/PI3CD is a novel IFN-beta triggered signalling cascade that regulates secreted IL-1Ra (sIL-1Ra) expression in monocytes and this provides a rationale for an alternative, interferon (IFN)-beta-mediated pathway to induce/enhance sIL-1Ra production, dampening inflammation.
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| Entrez Gene | |||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126934:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||
| Genomic Location | Chromosome 7:21132389-21153974 | ||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
ID pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TCR pathway
BCR pathway
IL1 pathway
IL2 pathway
IL5 pathway
IL6 pathway
IL-7 pathway
IL9 pathway
Leptin pathway
TSLP pathway
FSH pathway
Prolactin pathway
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| REACTOME |
RAF phosphorylates MEK pathway
MEK activation pathway
ERK2 activation pathway
ERK activation pathway
DAP12 signaling pathway
DAP12 interactions pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Interleukin-2 signaling pathway
Frs2-mediated activation pathway
ARMS-mediated activation pathway
Signalling to p38 via RIT and RIN pathway
Signalling to RAS pathway
SOS-mediated signalling pathway
SHC1 events in EGFR signaling pathway
GRB2 events in EGFR signaling pathway
Signaling by EGFR pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SHC1 events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
SHC-mediated signalling pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
SHC-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
GRB2 events in ERBB2 signaling pathway
SHC1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
FRS2-mediated cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Signal transduction by L1 pathway
L1CAM interactions pathway
NCAM signaling for neurite out-growth pathway
Signaling by FGFR in disease pathway
SHC-related events pathway
Developmental Biology pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Signaling by VEGF pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Uptake and actions of bacterial toxins pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Axon guidance pathway
RAF/MAP kinase cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
IRS-mediated signalling pathway
Immune System pathway
VEGFR2 mediated cell proliferation pathway
Insulin receptor signalling cascade pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Prolonged ERK activation events pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Uptake and function of anthrax toxins pathway
Disease pathway
Signaling by Leptin pathway
FCERI mediated MAPK activation pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Signaling by ERBB2 pathway
Disease pathway
SHC-related events pathway
RAF/MAP kinase cascade pathway
Signaling by GPCR pathway
Signaling by Insulin receptor pathway
Interleukin-2 signaling pathway
RAF phosphorylates MEK pathway
MyD88 cascade initiated on plasma membrane pathway
Signaling by VEGF pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
SHC1 events in ERBB2 signaling pathway
Cytokine Signaling in Immune system pathway
VEGFR2 mediated cell proliferation pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
SHC-mediated signalling pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
ERK activation pathway
SHC1 events in ERBB4 signaling pathway
Signalling to RAS pathway
SHC1 events in EGFR signaling pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Signaling by EGFR pathway
Frs2-mediated activation pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Toll-Like Receptors Cascades pathway
Signalling to ERKs pathway
Signaling by Interleukins pathway
MyD88 dependent cascade initiated on endosome pathway
Signal transduction by L1 pathway
L1CAM interactions pathway
Signalling by NGF pathway
Signaling by PDGF pathway
FRS2-mediated cascade pathway
Developmental Biology pathway
SOS-mediated signalling pathway
Activated TLR4 signalling pathway
IRS-related events pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-mediated signalling pathway
ERK2 activation pathway
ARMS-mediated activation pathway
MyD88-independent cascade pathway
Signal Transduction pathway
GRB2 events in ERBB2 signaling pathway
Signaling by Leptin pathway
Prolonged ERK activation events pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Signaling by FGFR pathway
GRB2 events in EGFR signaling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
FCERI mediated MAPK activation pathway
MEK activation pathway
SHC-related events triggered by IGF1R pathway
Signaling by EGFR in Cancer pathway
NCAM signaling for neurite out-growth pathway
Signalling to p38 via RIT and RIN pathway
DAP12 interactions pathway
DAP12 signaling pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Regulation of actin cytoskeleton pathway
GnRH signaling pathway pathway
Acute myeloid leukemia pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Gap junction pathway
Non-small cell lung cancer pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
MAPK signaling pathway pathway
Melanoma pathway
Thyroid cancer pathway
Endometrial cancer pathway
Long-term potentiation pathway
Bladder cancer pathway
Glioma pathway
Insulin signaling pathway pathway
B cell receptor signaling pathway pathway
Prostate cancer pathway
Long-term depression pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Chronic myeloid leukemia pathway
Melanogenesis pathway
Vascular smooth muscle contraction pathway
Neurotrophin signaling pathway pathway
Prion diseases pathway
Pathways in cancer pathway
Endometrial cancer pathway
Bladder cancer pathway
Renal cell carcinoma pathway
ErbB signaling pathway pathway
VEGF signaling pathway pathway
Insulin signaling pathway pathway
Acute myeloid leukemia pathway
T cell receptor signaling pathway pathway
Melanogenesis pathway
Toll-like receptor signaling pathway pathway
Gap junction pathway
Thyroid cancer pathway
Fc epsilon RI signaling pathway pathway
Melanoma pathway
Natural killer cell mediated cytotoxicity pathway
GnRH signaling pathway pathway
Regulation of actin cytoskeleton pathway
MAPK signaling pathway pathway
Long-term potentiation pathway
Glioma pathway
Prostate cancer pathway
Long-term depression pathway
Chronic myeloid leukemia pathway
Non-small cell lung cancer pathway
B cell receptor signaling pathway pathway
Vascular smooth muscle contraction pathway
Prion diseases pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
NGF signaling pathway pathway
IGF1 signaling pathway pathway
GPCR signaling pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
FGF8 signaling (Mouse) pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
GPCR Adenosine A2A receptor signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
HGF signaling pathway pathway
EGF signaling pathway pathway
NGF signaling pathway pathway
GPCR signaling pathway
PDGF signaling pathway pathway
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| PID NCI |
Ceramide signaling pathway
Cellular roles of Anthrax toxin
ErbB1 downstream signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
Fc-epsilon receptor I signaling in mast cells
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| Cross-References | |||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||
| UniGene | Bt.8367 | ||||||||||||||||||||||||||
| RefSeq | NM_001038071 | ||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||