InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HCK

Summary

InnateDB Gene

IDBG-64463.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HCK

Gene Name

hemopoietic cell kinase

Synonyms

JTK9; p59Hck; p61Hck

Species

Homo sapiens

Ensembl Gene

ENSG00000101336

Encoded Proteins

IDBP-64465

hemopoietic cell kinase

IDBP-64467

hemopoietic cell kinase

IDBP-64469

hemopoietic cell kinase

IDBP-482933

hemopoietic cell kinase

IDBP-476978

hemopoietic cell kinase

IDBP-473368

hemopoietic cell kinase

IDBP-590491

hemopoietic cell kinase

IDBP-584389

hemopoietic cell kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:32052188-32101856

Strand

Forward strand

Band

q11.21

Transcripts

ENST00000375862	ENSP00000365022
ENST00000375852	ENSP00000365012
ENST00000262651	ENSP00000262651
ENST00000486475	ENSP00000420457
ENST00000520553	ENSP00000429848
ENST00000518730	ENSP00000427757
ENST00000470092
ENST00000534862	ENSP00000444986
ENST00000538448	ENSP00000441169

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	72 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0002522	leukocyte migration involved in immune response
GO:0002758	innate immune response-activating signal transduction
GO:0006468	protein phosphorylation
GO:0006909	phagocytosis
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007498	mesoderm development
GO:0008284	positive regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0016032	viral process
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030838	positive regulation of actin filament polymerization
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043066	negative regulation of apoptotic process
GO:0043299	leukocyte degranulation
GO:0045087	innate immune response
GO:0045728	respiratory burst after phagocytosis
GO:0046777	protein autophosphorylation
GO:0050690	regulation of defense response to virus by virus
GO:0050727	regulation of inflammatory response
GO:0050764	regulation of phagocytosis
GO:0050830	defense response to Gram-positive bacterium
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0071801	regulation of podosome assembly
GO:2000251	positive regulation of actin cytoskeleton reorganization

Cellular Component

GO:0005634	nucleus
GO:0005764	lysosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005884	actin filament
GO:0005901	caveola
GO:0005925	focal adhesion
GO:0030133	transport vesicle
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0042995	cell projection