InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SKIL

Summary

InnateDB Gene

IDBG-64482.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SKIL

Gene Name

SKI-like oncogene

Synonyms

SNO; SnoA; SnoI; SnoN

Species

Homo sapiens

Ensembl Gene

ENSG00000136603

Encoded Proteins

IDBP-64484

SKI-like oncogene

IDBP-385289

SKI-like oncogene

IDBP-385290

SKI-like oncogene

IDBP-385291

SKI-like oncogene

IDBP-484253

SKI-like oncogene

IDBP-474641

SKI-like oncogene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:170357678-170396835

Strand

Forward strand

Band

q26.2

Transcripts

ENST00000259119	ENSP00000259119
ENST00000458537	ENSP00000415243
ENST00000426052	ENSP00000406520
ENST00000413427	ENSP00000400193
ENST00000477216
ENST00000465590
ENST00000476188	ENSP00000417670
ENST00000490989
ENST00000470571	ENSP00000418237
ENST00000490894

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 172 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	172 [view]
Protein-Protein	171 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0032403	protein complex binding
GO:0046332	SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001825	blastocyst formation
GO:0002260	lymphocyte homeostasis
GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007050	cell cycle arrest
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007283	spermatogenesis
GO:0007519	skeletal muscle tissue development
GO:0010467	gene expression
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0034097	response to cytokine
GO:0042981	regulation of apoptotic process
GO:0045596	negative regulation of cell differentiation
GO:0046677	response to antibiotic
GO:0050772	positive regulation of axonogenesis
GO:0070207	protein homotrimerization
GO:0070208	protein heterotrimerization
GO:0070306	lens fiber cell differentiation
GO:0070848	response to growth factor
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage