Bos taurus Gene: AP3B1
Summary
InnateDB Gene IDBG-645194.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP3B1
Gene Name AP-3 complex subunit beta-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005016
Encoded Proteins
AP-3 complex subunit beta-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] AP3B1 (AP-3), a lysosome-related organelle trafficking and biogenesis protein, is required for the production of pro-inflammatory cytokines in plasmacytoid dendritic cells upon recognition of viral nucleic acids by endosomal TLR7 or TLR9.
[Homo sapiens] AP3B1 is crucial for the trafficking of TLR9 to specific endosomal compartments for the induction of type I interferon.
[Mus musculus] Ap3b1 (AP-3), a lysosome-related organelle trafficking and biogenesis protein, is required for the production of pro-inflammatory cytokines in plasmacytoid dendritic cells upon recognition of viral nucleic acids by endosomal Tlr7 or Tlr9.
[Mus musculus] Ap3b1 is crucial for the trafficking of Tlr9 to specific endosomal compartments for the induction of type I interferon.
[Mus musculus] Cytokine activation as a result of Tlr2 stimulation is mediated by the phagosomal trafficking molecule Ap3b1 (AP-3).
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132842:
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:9040253-9300567
Strand Reverse strand
Band
Transcripts
ENSBTAT00000006605 ENSBTAP00000006605
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0019903 protein phosphatase binding
GO:0030742 GTP-dependent protein binding
Biological Process
GO:0006622 protein targeting to lysosome
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0007596 blood coagulation
GO:0008089 anterograde axon cargo transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0019882 antigen processing and presentation
GO:0032438 melanosome organization
GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib
GO:0048490 anterograde synaptic vesicle transport
GO:0051138 positive regulation of NK T cell differentiation
Cellular Component
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0030117 membrane coat
GO:0030123 AP-3 adaptor complex
GO:0030665 clathrin-coated vesicle membrane
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Golgi Associated Vesicle Biogenesis pathway
Clathrin derived vesicle budding pathway
trans-Golgi Network Vesicle Budding pathway
Membrane Trafficking pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
Golgi Associated Vesicle Biogenesis pathway
Membrane Trafficking pathway
Membrane Trafficking pathway
Golgi Associated Vesicle Biogenesis pathway
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
KEGG
Lysosome pathway
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q32PG1
TrEMBL
UniProt Splice Variant
Entrez Gene 767602
UniGene Bt.8350 Bt.87772
RefSeq NM_001076534
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC108129
GenPept AAI08130
RNA Seq Atlas 767602
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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