Version 5.4
Bos taurus Gene: CLIC4
Summary
InnateDB Gene IDBG-645329.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLIC4
Gene Name Chloride intracellular channel protein 4
Synonyms p64H1
Species Bos taurus
Ensembl Gene ENSBTAG00000009470
Encoded Proteins
IDBP-698034
Chloride intracellular channel protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169504:
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:128710453-128783921
Strand Reverse strand
Band
Transcripts
ENSBTAT00000054397 ENSBTAP00000048950
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001886 endothelial cell morphogenesis
GO:0006810 transport
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0007035 vacuolar acidification
GO:0009566 fertilization
GO:0030216 keratinocyte differentiation
GO:0030336 negative regulation of cell migration
GO:0034765 regulation of ion transmembrane transport
GO:0035264 multicellular organism growth
GO:0044070 regulation of anion transport
GO:0048754 branching morphogenesis of an epithelial tube
GO:0061299 retina vasculature morphogenesis in camera-type eye
GO:0071277 cellular response to calcium ion
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005911 cell-cell junction
GO:0009986 cell surface
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016363 nuclear matrix
GO:0030496 midbody
GO:0034707 chloride channel complex
GO:0045177 apical part of cell
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000169504
View Gene Order
ENSMUSG00000037242
View Gene Order
Cross-References
SwissProt Q9XSA7
TrEMBL
UniProt Splice Variant
Entrez Gene 286823
UniGene Bt.64763 Bt.75486
RefSeq NM_001080218
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF109198 BC103261
GenPept AAD26138 AAI03262
RNA Seq Atlas 286823

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca