InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MYH7

Summary

InnateDB Gene

IDBG-645780.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYH7

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009703

Encoded Proteins

IDBP-698533

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092054:
Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:21325414-21345624

Strand

Forward strand

Band

Transcripts

ENSBTAT00000061306

ENSBTAP00000053217

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0000166	nucleotide binding
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0030898	actin-dependent ATPase activity
GO:0051015	actin filament binding

Biological Process

GO:0001701	in utero embryonic development
GO:0002026	regulation of the force of heart contraction
GO:0002027	regulation of heart rate
GO:0006200	ATP catabolic process
GO:0006936	muscle contraction
GO:0006941	striated muscle contraction
GO:0007512	adult heart development
GO:0007522	visceral muscle development
GO:0008016	regulation of heart contraction
GO:0008217	regulation of blood pressure
GO:0030048	actin filament-based movement
GO:0030049	muscle filament sliding
GO:0030239	myofibril assembly
GO:0043462	regulation of ATPase activity
GO:0045214	sarcomere organization
GO:0048739	cardiac muscle fiber development
GO:0055009	atrial cardiac muscle tissue morphogenesis
GO:0055010	ventricular cardiac muscle tissue morphogenesis

Cellular Component

GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005925	focal adhesion
GO:0016459	myosin complex
GO:0030016	myofibril
GO:0030018	Z disc
GO:0032982	myosin filament