InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GHRL

Summary

InnateDB Gene

IDBG-646311.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GHRL

Gene Name

Appetite-regulating hormone Ghrelin Obestatin

Synonyms

Gh1-1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012328

Encoded Proteins

IDBP-699100

Appetite-regulating hormoneGhrelinObestatin

IDBP-699101

Appetite-regulating hormoneGhrelinObestatin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157017:
This gene encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:54945535-54950005

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000044304	ENSBTAP00000041811
ENSBTAT00000016350	ENSBTAP00000016350

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0016608	growth hormone-releasing hormone activity
GO:0030296	protein tyrosine kinase activator activity
GO:0031768	ghrelin receptor binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001937	negative regulation of endothelial cell proliferation
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008154	actin polymerization or depolymerization
GO:0008343	adult feeding behavior
GO:0009725	response to hormone
GO:0016358	dendrite development
GO:0032024	positive regulation of insulin secretion
GO:0032095	regulation of response to food
GO:0032097	positive regulation of response to food
GO:0032100	positive regulation of appetite
GO:0032691	negative regulation of interleukin-1 beta production
GO:0040013	negative regulation of locomotion
GO:0042127	regulation of cell proliferation
GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep
GO:0042536	negative regulation of tumor necrosis factor biosynthetic process
GO:0043066	negative regulation of apoptotic process
GO:0043627	response to estrogen
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep
GO:0046676	negative regulation of insulin secretion
GO:0046697	decidualization
GO:0050728	negative regulation of inflammatory response
GO:0051461	positive regulation of corticotropin secretion
GO:0051464	positive regulation of cortisol secretion
GO:0051965	positive regulation of synapse assembly
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060124	positive regulation of growth hormone secretion
GO:0061098	positive regulation of protein tyrosine kinase activity