InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SHANK1

Summary

InnateDB Gene

IDBG-64666.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SHANK1

Gene Name

SH3 and multiple ankyrin repeat domains 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000161681

Encoded Proteins

IDBP-64670

SH3 and multiple ankyrin repeat domains 1

IDBP-64672

SH3 and multiple ankyrin repeat domains 1

IDBP-246933

SH3 and multiple ankyrin repeat domains 1

IDBP-246935

SH3 and multiple ankyrin repeat domains 1

IDBP-760847

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:50661827-50719450

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000293441	ENSP00000293441
ENST00000359082	ENSP00000351984
ENST00000391814	ENSP00000375690
ENST00000391813	ENSP00000375689
ENST00000483981
ENST00000468654	ENSP00000469719
ENST00000461154
ENST00000483128

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	27 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0017124	SH3 domain binding
GO:0030159	receptor signaling complex scaffold activity
GO:0030160	GKAP/Homer scaffold activity
GO:0031877	somatostatin receptor binding
GO:0032403	protein complex binding
GO:0035255	ionotropic glutamate receptor binding
GO:0042802	identical protein binding
GO:0071532	ankyrin repeat binding
GO:0097110	scaffold protein binding

Biological Process

GO:0006461	protein complex assembly
GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0007616	long-term memory
GO:0008306	associative learning
GO:0030534	adult behavior
GO:0032232	negative regulation of actin filament bundle assembly
GO:0035176	social behavior
GO:0035418	protein localization to synapse
GO:0042048	olfactory behavior
GO:0046959	habituation
GO:0050885	neuromuscular process controlling balance
GO:0050894	determination of affect
GO:0060013	righting reflex
GO:0060074	synapse maturation
GO:0060997	dendritic spine morphogenesis
GO:0060999	positive regulation of dendritic spine development
GO:0071625	vocalization behavior
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0008328	ionotropic glutamate receptor complex
GO:0016020	membrane
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043005	neuron projection
GO:0043197	dendritic spine
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse
GO:0097481	neuronal postsynaptic density

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038738

View Gene Order

ENSBTAG00000013107

Not yet available

Cross-References

SwissProt

Q9Y566

TrEMBL

UniProt Splice Variant

Entrez Gene

50944

UniGene

Hs.274255

RefSeq

XM_006723234 NM_016148 XM_005258963 XM_006723233

HUGO

HGNC:15474

OMIM

604999

CCDS

CCDS12799

HPRD

05413

IMGT

EMBL

AC008743 AC010325 AF163302 AF226728

GenPept

AAD45121 AAF35887

RNA Seq Atlas

50944