Version 5.4
Bos taurus Gene: TDP1
Summary
InnateDB Gene IDBG-646924.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TDP1
Gene Name tyrosyl-DNA phosphodiesterase 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013138
Encoded Proteins
IDBP-699775
tyrosyl-DNA phosphodiesterase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000042088:
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:102697553-102766261
Strand Forward strand
Band
Transcripts
ENSBTAT00000017463 ENSBTAP00000017463
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0017005 3'-tyrosyl-DNA phosphodiesterase activity
Biological Process
GO:0000012 single strand break repair
GO:0006281 DNA repair
GO:0006302 double-strand break repair
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000042088
View Gene Order
ENSMUSG00000021177
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1201
Processing of DNA ends prior to end rejoining pathway
REACT_1022
Nonhomologous End-joining (NHEJ) pathway
REACT_2054
Double-Strand Break Repair pathway
REACT_216
DNA Repair pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MST1
UniProt Splice Variant
Entrez Gene 517053
UniGene Bt.26165
RefSeq NM_001193155 XM_005212186 XM_005212187 XM_005212188 XM_005212189 XM_005212190 XM_005212191
HUGO HGNC:18884
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02030029
GenPept
RNA Seq Atlas 517053

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca