InnateDB: Systems Biology of the Innate Immune Response

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified. [provided by RefSeq, Jul 2008]
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:64499616-64508199

Strand

Reverse strand

Band

q23.3

Transcripts

ENST00000225792	ENSP00000225792
ENST00000450599	ENSP00000403085
ENST00000540698	ENSP00000440276
ENST00000585060	ENSP00000465791
ENST00000580026
ENST00000583699
ENST00000581693	ENSP00000464566
ENST00000584549
ENST00000577922	ENSP00000464337
ENST00000577787	ENSP00000462222
ENST00000578758
ENST00000581230
ENST00000584279	ENSP00000462206
ENST00000583212	ENSP00000463903
ENST00000583562
ENST00000585317
ENST00000581697	ENSP00000464304
ENST00000581551
ENST00000579996	ENSP00000464659
ENST00000581237
ENST00000583894
ENST00000578804	ENSP00000462885
ENST00000578190	ENSP00000463541
ENST00000583239	ENSP00000463101
ENST00000578400	ENSP00000463975
ENST00000582326
ENST00000579091	ENSP00000464587
ENST00000585111	ENSP00000463168
ENST00000581806	ENSP00000464064
ENST00000585223
ENST00000583201
ENST00000584500
ENST00000579461
ENST00000578491

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 230 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	230 [view]
Protein-Protein	221 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	6 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0003724	RNA helicase activity
GO:0004004	ATP-dependent RNA helicase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0019899	enzyme binding
GO:0030331	estrogen receptor binding
GO:0036002	pre-mRNA binding
GO:0044822	poly(A) RNA binding
GO:0048306	calcium-dependent protein binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0001701	in utero embryonic development
GO:0006200	ATP catabolic process
GO:0006351	transcription, DNA-templated
GO:0007623	circadian rhythm
GO:0016049	cell growth
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045069	regulation of viral genome replication
GO:0045667	regulation of osteoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060765	regulation of androgen receptor signaling pathway
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
GO:2001014	regulation of skeletal muscle cell differentiation
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020719

View Gene Order

ENSBTAG00000018423

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

NetPath_7

TGF_beta_Receptor pathway

REACTOME

KEGG

hsa03040

Spliceosome pathway

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.279806 Hs.717931 Hs.733208

RefSeq

NM_004396 XM_005257111 XM_006721738

HUGO

OMIM

CCDS

CCDS11659

HPRD

01615

IMGT

EMBL

GenPept

RNA Seq Atlas