InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CLTA

Summary

InnateDB Gene

IDBG-64915.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLTA

Gene Name

clathrin, light chain A

Synonyms

LCA

Species

Homo sapiens

Ensembl Gene

ENSG00000122705

Encoded Proteins

IDBP-64917

clathrin, light chain A

IDBP-64919

clathrin, light chain A

IDBP-237159

clathrin, light chain A

IDBP-369134

clathrin, light chain A

IDBP-484690

clathrin, light chain A

IDBP-480711

clathrin, light chain A

IDBP-483102

clathrin, light chain A

IDBP-806875

clathrin, light chain A

IDBP-589273

clathrin, light chain A

IDBP-595136

clathrin, light chain A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:36190856-36304781

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000345519	ENSP00000242284
ENST00000242285	ENSP00000242285
ENST00000396603	ENSP00000379848
ENST00000433436	ENSP00000401019
ENST00000464497	ENSP00000419158
ENST00000470744	ENSP00000419746
ENST00000466396	ENSP00000417698
ENST00000493185	ENSP00000474266
ENST00000538225	ENSP00000442869
ENST00000540080	ENSP00000437508

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0032050	clathrin heavy chain binding
GO:0042277	peptide binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0006897	endocytosis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007411	axon guidance
GO:0016192	vesicle-mediated transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0061024	membrane organization

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030118	clathrin coat
GO:0030130	clathrin coat of trans-Golgi network vesicle
GO:0030132	clathrin coat of coated pit
GO:0030136	clathrin-coated vesicle
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0032588	trans-Golgi network membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0071439	clathrin complex