Version 5.4
Homo sapiens Gene: RAB18
Summary
InnateDB Gene IDBG-64998.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB18
Gene Name RAB18, member RAS oncogene family
Synonyms RAB18LI1; WARBM3
Species Homo sapiens
Ensembl Gene ENSG00000099246
Encoded Proteins
IDBP-65000
RAB18, member RAS oncogene family
IDBP-65004
RAB18, member RAS oncogene family
IDBP-371077
RAB18, member RAS oncogene family
IDBP-583663
RAB18, member RAS oncogene family
IDBP-810169
RAB18, member RAS oncogene family
IDBP-810171
RAB18, member RAS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:27504174-27542237
Strand Forward strand
Band p12.1
Transcripts
ENST00000356940 ENSP00000349415
ENST00000375802 ENSP00000364960
ENST00000423465 ENSP00000407872
ENST00000490236
ENST00000465772
ENST00000484281
ENST00000535776 ENSP00000439321
ENST00000621805 ENSP00000478479
ENST00000611151 ENSP00000483927
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
Biological Process
GO:0001654 eye development
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007420 brain development
GO:0015031 protein transport
GO:0034389 lipid particle organization
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000073639
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 22931
UniGene Hs.613682
RefSeq NM_001256410 NM_001256411 NM_001256412 NM_001256415 NM_021252
HUGO HGNC:14244
OMIM 602207
CCDS CCDS58073 CCDS7155 CCDS73080 CCDS73081
HPRD 03731
IMGT
EMBL
GenPept
RNA Seq Atlas 22931

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca