InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ULK1

Summary

InnateDB Gene

IDBG-65053.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ULK1

Gene Name

unc-51-like kinase 1 (C. elegans)

Synonyms

ATG1; ATG1A; hATG1; UNC51; Unc51.1

Species

Homo sapiens

Ensembl Gene

ENSG00000177169

Encoded Proteins

IDBP-65055

unc-51-like kinase 1 (C. elegans)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25792739

Stimulation of TMEM173-dependent IRF3 activation by ultraviolet radiation is due to apoptotic signalling-dependent disruption of ULK1, a pro-autophagic protein that negatively regulates TMEM173.

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:131894651-131923167

Strand

Forward strand

Band

q24.33

Transcripts

ENST00000321867	ENSP00000324560
ENST00000537421
ENST00000542313
ENST00000541761
ENST00000540647
ENST00000544718
ENST00000540568

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	78 [view]
Protein-Protein	75 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0017137	Rab GTPase binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007265	Ras protein signal transduction
GO:0007409	axonogenesis
GO:0008104	protein localization
GO:0009103	lipopolysaccharide biosynthetic process
GO:0010506	regulation of autophagy
GO:0010508	positive regulation of autophagy
GO:0016239	positive regulation of macroautophagy
GO:0021707	cerebellar granule cell differentiation
GO:0021933	radial glia guided migration of cerebellar granule cell
GO:0031102	neuron projection regeneration
GO:0031175	neuron projection development
GO:0031623	receptor internalization
GO:0031669	cellular response to nutrient levels
GO:0042594	response to starvation
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation
GO:0048671	negative regulation of collateral sprouting
GO:0048675	axon extension
GO:0051386	regulation of neurotrophin TRK receptor signaling pathway

Cellular Component

GO:0000407	pre-autophagosomal structure
GO:0005737	cytoplasm
GO:0005776	autophagic vacuole
GO:0005829	cytosol
GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0034045	pre-autophagosomal structure membrane
GO:0034273	ATG1/UKL1 signaling complex
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0070969	ULK1-ATG13-FIP200 complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029512

View Gene Order

ENSBTAG00000012987

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04150

mTOR signaling pathway pathway

hsa04140

Regulation of autophagy pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.47061 Hs.619251

RefSeq

NM_003565

HUGO

OMIM

CCDS

CCDS9274

HPRD

11933

IMGT

EMBL

GenPept

RNA Seq Atlas