Version 5.4
Homo sapiens Gene: GPLD1
Summary
InnateDB Gene IDBG-65072.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPLD1
Gene Name glycosylphosphatidylinositol specific phospholipase D1
Synonyms GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; PLD
Species Homo sapiens
Ensembl Gene ENSG00000112293
Encoded Proteins
IDBP-65074
glycosylphosphatidylinositol specific phospholipase D1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:24424565-24495205
Strand Reverse strand
Band p22.3
Transcripts
ENST00000230036 ENSP00000230036
ENST00000378243
ENST00000492917
ENST00000474784
ENST00000486892
ENST00000475417
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004621 glycosylphosphatidylinositol phospholipase D activity
GO:0004630 phospholipase D activity
GO:0005515 protein binding
GO:0017080 sodium channel regulator activity
Biological Process
GO:0001503 ossification
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002062 chondrocyte differentiation
GO:0002430 complement receptor mediated signaling pathway
GO:0006507 GPI anchor release
GO:0008285 negative regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009749 response to glucose
GO:0010595 positive regulation of endothelial cell migration
GO:0010694 positive regulation of alkaline phosphatase activity
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010897 negative regulation of triglyceride catabolic process
GO:0010907 positive regulation of glucose metabolic process
GO:0010983 positive regulation of high-density lipoprotein particle clearance
GO:0032869 cellular response to insulin stimulus
GO:0035690 cellular response to drug
GO:0035701 hematopoietic stem cell migration
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0043065 positive regulation of apoptotic process
GO:0045919 positive regulation of cytolysis
GO:0046470 phosphatidylcholine metabolic process
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051047 positive regulation of secretion
GO:0070633 transepithelial transport
GO:0071277 cellular response to calcium ion
GO:0071397 cellular response to cholesterol
GO:0071401 cellular response to triglyceride
GO:0071467 cellular response to pH
GO:0097241 hematopoietic stem cell migration to bone marrow
GO:1900076 regulation of cellular response to insulin stimulus
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021340
View Gene Order
ENSBTAG00000004982
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Cross-References
SwissProt P80108
TrEMBL
UniProt Splice Variant
Entrez Gene 2822
UniGene Hs.533291
RefSeq NM_001503
HUGO HGNC:4459
OMIM 602515
CCDS CCDS4553
HPRD
IMGT
EMBL AJ308108 AJ400872 AJ400873 AJ400874 AJ400875 AJ400876 AL031230 AL359713 AY007546 BC007614 BC020748 BC093645 BC112001 L11701 L11702
GenPept AAA36444 AAA36445 AAG16627 AAH07614 AAH20748 AAH93645 AAI12002 CAC14844 CAC87068 CAD92520 CAI17103 CAI22602
RNA Seq Atlas 2822

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca