Version 5.4
Homo sapiens Gene: GHSR
Summary
InnateDB Gene IDBG-65129.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GHSR
Gene Name growth hormone secretagogue receptor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000121853
Encoded Proteins
IDBP-65131
growth hormone secretagogue receptor
IDBP-385446
growth hormone secretagogue receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:172445133-172448456
Strand Reverse strand
Band q26.31
Transcripts
ENST00000241256 ENSP00000241256
ENST00000427970 ENSP00000395344
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001616 growth hormone secretagogue receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0016520 growth hormone-releasing hormone receptor activity
GO:0017046 peptide hormone binding
GO:0042562 hormone binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008154 actin polymerization or depolymerization
GO:0008343 adult feeding behavior
GO:0009725 response to hormone
GO:0009755 hormone-mediated signaling pathway
GO:0030252 growth hormone secretion
GO:0032094 response to food
GO:0032100 positive regulation of appetite
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032869 cellular response to insulin stimulus
GO:0040018 positive regulation of multicellular organism growth
GO:0042536 negative regulation of tumor necrosis factor biosynthetic process
GO:0043134 regulation of hindgut contraction
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045409 negative regulation of interleukin-6 biosynthetic process
GO:0045923 positive regulation of fatty acid metabolic process
GO:0046676 negative regulation of insulin secretion
GO:0046697 decidualization
GO:0050728 negative regulation of inflammatory response
GO:0051963 regulation of synapse assembly
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0043005 neuron projection
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051136
View Gene Order
ENSBTAG00000010874
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt Q92847
TrEMBL A2T3X1
UniProt Splice Variant
Entrez Gene 2693
UniGene Hs.130212
RefSeq NM_004122 NM_198407
HUGO HGNC:4267
OMIM 601898
CCDS CCDS46959 CCDS3218
HPRD 03541
IMGT
EMBL AF369786 AY322544 AY429112 BC069068 BC069374 BC113547 CH471052 DQ864722 U60179 U60181
GenPept AAC50653 AAC50654 AAH69068 AAH69374 AAI13548 AAK71539 AAK71540 AAP84357 AAR07907 ABN09829 EAW78468
RNA Seq Atlas 2693

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca