InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ECT2

Summary

InnateDB Gene

IDBG-65239.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ECT2

Gene Name

epithelial cell transforming sequence 2 oncogene

Synonyms

ARHGEF31

Species

Homo sapiens

Ensembl Gene

ENSG00000114346

Encoded Proteins

IDBP-65241

epithelial cell transforming sequence 2 oncogene

IDBP-385489

epithelial cell transforming sequence 2 oncogene

IDBP-385488

epithelial cell transforming sequence 2 oncogene

IDBP-245133

epithelial cell transforming sequence 2 oncogene

IDBP-385484

epithelial cell transforming sequence 2 oncogene

IDBP-385486

epithelial cell transforming sequence 2 oncogene

IDBP-385487

epithelial cell transforming sequence 2 oncogene

IDBP-385490

epithelial cell transforming sequence 2 oncogene

IDBP-385491

epithelial cell transforming sequence 2 oncogene

IDBP-385493

epithelial cell transforming sequence 2 oncogene

IDBP-385494

epithelial cell transforming sequence 2 oncogene

IDBP-385495

epithelial cell transforming sequence 2 oncogene

IDBP-586680

epithelial cell transforming sequence 2 oncogene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:172750682-172821474

Strand

Forward strand

Band

q26.31

Transcripts

ENST00000232458	ENSP00000232458
ENST00000366254	ENSP00000391695
ENST00000366090	ENSP00000403446
ENST00000392692	ENSP00000376457
ENST00000417960	ENSP00000415876
ENST00000428567	ENSP00000403501
ENST00000426894	ENSP00000412331
ENST00000415665	ENSP00000412028
ENST00000438041	ENSP00000389108
ENST00000441497	ENSP00000412259
ENST00000444250	ENSP00000411674
ENST00000437296	ENSP00000397788
ENST00000460860
ENST00000486027
ENST00000487073
ENST00000540509	ENSP00000443160

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 151 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	151 [view]
Protein-Protein	151 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0017048	Rho GTPase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000902	cell morphogenesis
GO:0000910	cytokinesis
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0032147	activation of protein kinase activity
GO:0032321	positive regulation of Rho GTPase activity
GO:0032467	positive regulation of cytokinesis
GO:0032862	activation of Rho GTPase activity
GO:0032863	activation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0042307	positive regulation of protein import into nucleus
GO:0043065	positive regulation of apoptotic process
GO:0043089	positive regulation of Cdc42 GTPase activity
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043547	positive regulation of GTPase activity
GO:0045666	positive regulation of neuron differentiation
GO:0045859	regulation of protein kinase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051260	protein homooligomerization
GO:0051988	regulation of attachment of spindle microtubules to kinetochore
GO:0070301	cellular response to hydrogen peroxide
GO:0070830	tight junction assembly
GO:0071277	cellular response to calcium ion
GO:0071479	cellular response to ionizing radiation
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0030496	midbody
GO:0032154	cleavage furrow
GO:0072686	mitotic spindle
GO:0097149	centralspindlin complex