Version 5.4
| Homo sapiens Gene: KLK7 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-65268.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | KLK7 | ||||||||||||||||||
| Gene Name | kallikrein-related peptidase 7 | ||||||||||||||||||
| Synonyms | hK7; PRSS6; SCCE | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000169035 | ||||||||||||||||||
| Encoded Proteins |
kallikrein-related peptidase 7
kallikrein-related peptidase 7
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 19:50976482-50984099 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q13.41 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P49862 | ||||||||||||||||||
| TrEMBL | A0A024R4H6 B4DHX9 M0QYU8 X2J289 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 5650 | ||||||||||||||||||
| UniGene | Hs.151254 | ||||||||||||||||||
| RefSeq | NM_139277 NM_001207053 NM_001243126 NM_005046 | ||||||||||||||||||
| HUGO | HGNC:6368 | ||||||||||||||||||
| OMIM | 604438 | ||||||||||||||||||
| CCDS | CCDS12812 CCDS59414 | ||||||||||||||||||
| HPRD | 05115 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC011483 AF166330 AF243527 AF332583 AF411214 AF411215 AK289660 AK295313 AY601109 BC032005 CH471135 KF963189 L33404 | ||||||||||||||||||
| GenPept | AAC37551 AAD49718 AAG33360 AAH32005 AAK69624 AAN03662 AAN03663 AAU04540 AHN52223 BAF82349 BAG58291 EAW71959 EAW71960 EAW71961 | ||||||||||||||||||
| RNA Seq Atlas | 5650 | ||||||||||||||||||