InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KLK8

Summary

InnateDB Gene

IDBG-65297.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLK8

Gene Name

kallikrein-related peptidase 8

Synonyms

HNP; NP; NRPN; PRSS19; TADG14

Species

Homo sapiens

Ensembl Gene

ENSG00000129455

Encoded Proteins

IDBP-65299

kallikrein-related peptidase 8

IDBP-65301

kallikrein-related peptidase 8

IDBP-65303

kallikrein-related peptidase 8

IDBP-246949

kallikrein-related peptidase 8

IDBP-759743

IDBP-763920

IDBP-760436

IDBP-760407

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer. [provided by RefSeq, Jul 2008]
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:50996007-51002711

Strand

Reverse strand

Band

q13.41

Transcripts

ENST00000291726	ENSP00000291726
ENST00000347619	ENSP00000341555
ENST00000320838	ENSP00000325072
ENST00000391806	ENSP00000375682
ENST00000593490	ENSP00000469278
ENST00000595238	ENSP00000472273
ENST00000594669	ENSP00000473067
ENST00000594914
ENST00000598195
ENST00000599710
ENST00000600767	ENSP00000472016

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0007613	memory
GO:0008219	cell death
GO:0009611	response to wounding
GO:0031642	negative regulation of myelination
GO:0043616	keratinocyte proliferation
GO:0048681	negative regulation of axon regeneration
GO:0048812	neuron projection morphogenesis
GO:0050807	regulation of synapse organization
GO:0050808	synapse organization

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000064023

View Gene Order

ENSBTAG00000015128

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.104570

RefSeq

NM_001281431 NM_007196 NM_144505 NM_144506 NM_144507

HUGO

OMIM

CCDS

CCDS12813 CCDS12814 CCDS12815 CCDS42600 CCDS74433

HPRD

05733

IMGT

EMBL

GenPept

RNA Seq Atlas