Version 5.4
Homo sapiens Gene: HELZ
Summary
InnateDB Gene IDBG-65362.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HELZ
Gene Name helicase with zinc finger
Synonyms DHRC; DRHC; HUMORF5
Species Homo sapiens
Ensembl Gene ENSG00000198265
Encoded Proteins
IDBP-65364
helicase with zinc finger
IDBP-377456
helicase with zinc finger
IDBP-761952
IDBP-757753
IDBP-762504
IDBP-760769
IDBP-759895
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:67070438-67245989
Strand Reverse strand
Band q24.2
Transcripts
ENST00000358691 ENSP00000351524
ENST00000417253 ENSP00000411144
ENST00000580168 ENSP00000464512
ENST00000579953 ENSP00000463727
ENST00000578938
ENST00000580662
ENST00000584641
ENST00000579861 ENSP00000462320
ENST00000581159 ENSP00000462763
ENST00000578783 ENSP00000464354
ENST00000580963
ENST00000582864
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020721
View Gene Order
ENSBTAG00000004746
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.370140 Hs.597170 Hs.607072
RefSeq NM_014877 XM_005257889
HUGO
OMIM
CCDS CCDS42374
HPRD 10452
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca