Version 5.4
Homo sapiens Gene: KLK13
Summary
InnateDB Gene IDBG-65576.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLK13
Gene Name kallikrein-related peptidase 13
Synonyms KLK-L4; KLKL4
Species Homo sapiens
Ensembl Gene ENSG00000167759
Encoded Proteins
IDBP-65578
kallikrein-related peptidase 13
IDBP-65580
kallikrein-related peptidase 13
IDBP-65584
kallikrein-related peptidase 13
IDBP-384009
kallikrein-related peptidase 13
IDBP-760995
IDBP-762629
IDBP-760718
IDBP-765607
IDBP-765187
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:51056206-51065114
Strand Reverse strand
Band q13.41
Transcripts
ENST00000156476 ENSP00000156476
ENST00000335422 ENSP00000334079
ENST00000376799 ENSP00000365995
ENST00000441527 ENSP00000392640
ENST00000596955 ENSP00000472248
ENST00000602090 ENSP00000472596
ENST00000595793 ENSP00000470555
ENST00000601975 ENSP00000470931
ENST00000595547 ENSP00000470245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0016485 protein processing
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0030141 secretory granule
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054046
View Gene Order
ENSBTAG00000009382
Not yet available
Pathways
NETPATH
REACTOME
REACT_15428
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.165296
RefSeq NM_015596
HUGO
OMIM
CCDS CCDS12822
HPRD 05693
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca