InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAPRE1

Summary

InnateDB Gene

IDBG-65652.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPRE1

Gene Name

microtubule-associated protein, RP/EB family, member 1

Synonyms

EB1

Species

Homo sapiens

Ensembl Gene

ENSG00000101367

Encoded Proteins

IDBP-65654

microtubule-associated protein, RP/EB family, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:32819893-32850405

Strand

Forward strand

Band

q11.21

Transcripts

ENST00000375571

ENSP00000364721

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	54 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008022	protein C-terminus binding
GO:0044822	poly(A) RNA binding
GO:0051010	microtubule plus-end binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0008283	cell proliferation
GO:0031115	negative regulation of microtubule polymerization
GO:0035372	protein localization to microtubule
GO:1903033	positive regulation of microtubule plus-end binding

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005881	cytoplasmic microtubule
GO:0015630	microtubule cytoskeleton
GO:0030981	cortical microtubule cytoskeleton
GO:0031253	cell projection membrane
GO:0035371	microtubule plus-end
GO:0042995	cell projection