InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GMNN

Summary

InnateDB Gene

IDBG-65780.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GMNN

Gene Name

geminin, DNA replication inhibitor

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000112312

Encoded Proteins

IDBP-65782

geminin, DNA replication inhibitor

IDBP-65784

geminin, DNA replication inhibitor

IDBP-65786

geminin, DNA replication inhibitor

IDBP-65788

geminin, DNA replication inhibitor

IDBP-476930

geminin, DNA replication inhibitor

IDBP-806458

geminin, DNA replication inhibitor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:24774931-24786099

Strand

Forward strand

Band

p22.3

Transcripts

ENST00000356509	ENSP00000348902
ENST00000230056	ENSP00000230056
ENST00000378059	ENSP00000367298
ENST00000378054	ENSP00000367293
ENST00000468943
ENST00000476555	ENSP00000419584
ENST00000620958	ENSP00000477506

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042826	histone deacetylase binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006275	regulation of DNA replication
GO:0006461	protein complex assembly
GO:0008156	negative regulation of DNA replication
GO:0009887	organ morphogenesis
GO:0045786	negative regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated