Version 5.4
Homo sapiens Gene: BCL2L11
Summary
InnateDB Gene IDBG-65821.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL2L11
Gene Name BCL2-like 11 (apoptosis facilitator)
Synonyms BAM; BIM; BOD
Species Homo sapiens
Ensembl Gene ENSG00000153094
Encoded Proteins
IDBP-65825
BCL2-like 11 (apoptosis facilitator)
IDBP-65829
BCL2-like 11 (apoptosis facilitator)
IDBP-65831
BCL2-like 11 (apoptosis facilitator)
IDBP-65833
BCL2-like 11 (apoptosis facilitator)
IDBP-243987
BCL2-like 11 (apoptosis facilitator)
IDBP-243991
BCL2-like 11 (apoptosis facilitator)
IDBP-294838
BCL2-like 11 (apoptosis facilitator)
IDBP-384614
BCL2-like 11 (apoptosis facilitator)
IDBP-384621
BCL2-like 11 (apoptosis facilitator)
IDBP-384625
BCL2-like 11 (apoptosis facilitator)
IDBP-384630
BCL2-like 11 (apoptosis facilitator)
IDBP-384633
BCL2-like 11 (apoptosis facilitator)
IDBP-384634
BCL2-like 11 (apoptosis facilitator)
IDBP-384635
BCL2-like 11 (apoptosis facilitator)
IDBP-384638
BCL2-like 11 (apoptosis facilitator)
IDBP-384640
BCL2-like 11 (apoptosis facilitator)
IDBP-809854
BCL2-like 11 (apoptosis facilitator)
IDBP-809856
BCL2-like 11 (apoptosis facilitator)
IDBP-809857
BCL2-like 11 (apoptosis facilitator)
IDBP-809858
BCL2-like 11 (apoptosis facilitator)
IDBP-809859
BCL2-like 11 (apoptosis facilitator)
IDBP-809860
BCL2-like 11 (apoptosis facilitator)
IDBP-809861
BCL2-like 11 (apoptosis facilitator)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:111119378-111168447
Strand Forward strand
Band q13
Transcripts
ENST00000337565 ENSP00000338374
ENST00000308659 ENSP00000309226
ENST00000357757 ENSP00000350398
ENST00000361493 ENSP00000354879
ENST00000393256 ENSP00000376943
ENST00000393252 ENSP00000376941
ENST00000405953 ENSP00000384641
ENST00000432179 ENSP00000411870
ENST00000433098 ENSP00000401662
ENST00000439718 ENSP00000411137
ENST00000431217 ENSP00000394640
ENST00000436733 ENSP00000403727
ENST00000415458 ENSP00000393781
ENST00000452231 ENSP00000391292
ENST00000437029 ENSP00000412892
ENST00000438054 ENSP00000389225
ENST00000619294 ENSP00000479714
ENST00000610735 ENSP00000481030
ENST00000622509 ENSP00000482175
ENST00000615946 ENSP00000481423
ENST00000622612 ENSP00000484360
ENST00000621302 ENSP00000481652
ENST00000620862 ENSP00000478133
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 81 [view]
Protein-Protein 77 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001776 leukocyte homeostasis
GO:0001782 B cell homeostasis
GO:0001783 B cell apoptotic process
GO:0001822 kidney development
GO:0002260 lymphocyte homeostasis
GO:0002262 myeloid cell homeostasis
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007160 cell-matrix adhesion
GO:0007283 spermatogenesis
GO:0007420 brain development
GO:0008584 male gonad development
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009791 post-embryonic development
GO:0010942 positive regulation of cell death
GO:0030879 mammary gland development
GO:0032464 positive regulation of protein homooligomerization
GO:0034976 response to endoplasmic reticulum stress
GO:0035148 tube formation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042981 regulation of apoptotic process
GO:0043029 T cell homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043583 ear development
GO:0045787 positive regulation of cell cycle
GO:0046620 regulation of organ growth
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048066 developmental pigmentation
GO:0048070 regulation of developmental pigmentation
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048563 post-embryonic organ morphogenesis
GO:0060139 positive regulation of apoptotic process by virus
GO:0060154 cellular process regulating host cell cycle in response to virus
GO:0070242 thymocyte apoptotic process
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097190 apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902263 apoptotic process involved in embryonic digit morphogenesis
GO:2000271 positive regulation of fibroblast apoptotic process
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0005874 microtubule
GO:0012505 endomembrane system
GO:0019898 extrinsic component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0097140 BIM-BCL-xl complex
GO:0097141 BIM-BCL-2 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027381
View Gene Order
ENSBTAG00000024105
Not yet available
Pathways
NETPATH
NetPath_12
BCR pathway
NetPath_15
IL3 pathway
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_1650
Activation of BIM and translocation to mitochondria pathway
REACT_330
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
REACT_11061
Signalling by NGF pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
KEGG
INOH
PID NCI
foxopathway
FoxO family signaling
ap1_pathway
AP-1 transcription factor network
p75ntrpathway
p75(NTR)-mediated signaling
p73pathway
p73 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.737004
RefSeq NM_001204106 NM_001204107 NM_001204108 NM_001204109 NM_001204110 NM_001204111 NM_001204112 NM_001204113 NM_006538 NM_138621 NM_138622 NM_138623 NM_138624 NM_138626 NM_138627 NM_207002 NM_207003 XM_005263551 XM_005263553 XM_005263554 XM_005263559 XM_005263560
HUGO
OMIM
CCDS CCDS2089 CCDS2092 CCDS42731 CCDS56131 CCDS56132 CCDS56133 CCDS56134 CCDS56135 CCDS56136 CCDS74559 CCDS74560 CCDS74561
HPRD 04828
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca