Version 5.4
Homo sapiens Gene: TBL1XR1
Summary
InnateDB Gene IDBG-65899.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBL1XR1
Gene Name transducin (beta)-like 1 X-linked receptor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000177565
Encoded Proteins
IDBP-65903
transducin (beta)-like 1 X-linked receptor 1
IDBP-385534
transducin (beta)-like 1 X-linked receptor 1
IDBP-385535
transducin (beta)-like 1 X-linked receptor 1
IDBP-385537
transducin (beta)-like 1 X-linked receptor 1
IDBP-385538
transducin (beta)-like 1 X-linked receptor 1
IDBP-385539
transducin (beta)-like 1 X-linked receptor 1
IDBP-385541
transducin (beta)-like 1 X-linked receptor 1
IDBP-385543
transducin (beta)-like 1 X-linked receptor 1
IDBP-385544
transducin (beta)-like 1 X-linked receptor 1
IDBP-385545
transducin (beta)-like 1 X-linked receptor 1
IDBP-385546
transducin (beta)-like 1 X-linked receptor 1
IDBP-385548
transducin (beta)-like 1 X-linked receptor 1
IDBP-385550
transducin (beta)-like 1 X-linked receptor 1
IDBP-385551
transducin (beta)-like 1 X-linked receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:177019355-177197473
Strand Reverse strand
Band q26.32
Transcripts
ENST00000352800 ENSP00000263964
ENST00000430069 ENSP00000405574
ENST00000457928 ENSP00000413251
ENST00000428970 ENSP00000391559
ENST00000424913 ENSP00000404863
ENST00000431421 ENSP00000402402
ENST00000437738 ENSP00000392180
ENST00000450267 ENSP00000406297
ENST00000431674 ENSP00000397450
ENST00000422066 ENSP00000398477
ENST00000443315 ENSP00000396120
ENST00000422442 ENSP00000387849
ENST00000427349 ENSP00000401044
ENST00000413084 ENSP00000415506
ENST00000474363
ENST00000491623
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 38 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0042393 histone binding
GO:0044212 transcription regulatory region DNA binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007219 Notch signaling pathway
GO:0016568 chromatin modification
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060070 canonical Wnt signaling pathway
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005876 spindle microtubule
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027630
View Gene Order
ENSBTAG00000021910
Not yet available
Pathways
NETPATH
REACTOME
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_118659
RORA activates circadian gene expression pathway
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_118789
REV-ERBA represses gene expression pathway
REACT_24941
Circadian Clock pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_118713
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_111045
Developmental Biology pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_267716
Orphan transporters pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_172623
Chromatin organization pathway
REACT_299
Signaling by NOTCH pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_111217
Metabolism pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt
TrEMBL C9IYU9 C9J3H2 C9J7E1 C9J903 C9JCW4 C9JEC9 C9JLJ1 C9JTW8 C9JY82
UniProt Splice Variant
Entrez Gene 79718
UniGene Hs.581171 Hs.622385 Hs.644678 Hs.715026 Hs.742261
RefSeq NM_024665 XM_005247771 XM_005247772 XM_005247775 XM_005247776 XM_006713745 XM_006713746
HUGO HGNC:29529
OMIM 608628
CCDS CCDS46961
HPRD 15476
IMGT
EMBL AC023235 AC078799
GenPept
RNA Seq Atlas 79718

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca