Version 5.4
Homo sapiens Gene: ANKLE2
Summary
InnateDB Gene IDBG-65913.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANKLE2
Gene Name ankyrin repeat and LEM domain containing 2
Synonyms KIAA0692; Lem4; LEMD7
Species Homo sapiens
Ensembl Gene ENSG00000176915
Encoded Proteins
IDBP-65915
ankyrin repeat and LEM domain containing 2
IDBP-586369
ankyrin repeat and LEM domain containing 2
IDBP-594049
ankyrin repeat and LEM domain containing 2
IDBP-591792
ankyrin repeat and LEM domain containing 2
IDBP-603242
ankyrin repeat and LEM domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:132725503-132761888
Strand Reverse strand
Band q24.33
Transcripts
ENST00000357997 ENSP00000350686
ENST00000439231
ENST00000505031
ENST00000539605
ENST00000542282 ENSP00000437807
ENST00000542657 ENSP00000438551
ENST00000542374
ENST00000538766 ENSP00000445760
ENST00000538591
ENST00000535036 ENSP00000437585
ENST00000545623
ENST00000546061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0007067 mitotic nuclear division
GO:0007084 mitotic nuclear envelope reassembly
GO:0035307 positive regulation of protein dephosphorylation
GO:0042326 negative regulation of phosphorylation
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029501
View Gene Order
ENSBTAG00000033339
Not yet available
Pathways
NETPATH
REACTOME
REACT_160242
Initiation of Nuclear Envelope Reformation pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_160113
Nuclear Envelope Reassembly pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654628 Hs.666964
RefSeq NM_015114 XM_005266159 XM_005266160 XM_005266161
HUGO
OMIM
CCDS CCDS41869
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca