InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GNG2

Summary

InnateDB Gene

IDBG-6595.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNG2

Gene Name

guanine nucleotide binding protein (G protein), gamma 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000186469

Encoded Proteins

IDBP-6597

guanine nucleotide binding protein (G protein), gamma 2

IDBP-601851

guanine nucleotide binding protein (G protein), gamma 2

IDBP-584221

guanine nucleotide binding protein (G protein), gamma 2

IDBP-595239

guanine nucleotide binding protein (G protein), gamma 2

IDBP-599279

guanine nucleotide binding protein (G protein), gamma 2

IDBP-583308

guanine nucleotide binding protein (G protein), gamma 2

IDBP-602743

guanine nucleotide binding protein (G protein), gamma 2

IDBP-593675

guanine nucleotide binding protein (G protein), gamma 2

IDBP-600551

guanine nucleotide binding protein (G protein), gamma 2

IDBP-588660

guanine nucleotide binding protein (G protein), gamma 2

IDBP-807421

guanine nucleotide binding protein (G protein), gamma 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:51826195-51979342

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000335281	ENSP00000334448
ENST00000553432	ENSP00000451279
ENST00000556522	ENSP00000450904
ENST00000557376	ENSP00000450758
ENST00000553560	ENSP00000450586
ENST00000554832
ENST00000553299
ENST00000557208
ENST00000555472	ENSP00000451102
ENST00000556766	ENSP00000451231
ENST00000554840
ENST00000554736	ENSP00000452014
ENST00000556752	ENSP00000451576
ENST00000556471
ENST00000554875	ENSP00000451536
ENST00000615906	ENSP00000484021

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0031681	G-protein beta-subunit binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0030168	platelet activation
GO:0044281	small molecule metabolic process
GO:0071377	cellular response to glucagon stimulus
GO:0071380	cellular response to prostaglandin E stimulus
GO:0071870	cellular response to catecholamine stimulus

Cellular Component

GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000043004

View Gene Order

ENSBTAG00000003043

Not yet available

Pathways

NETPATH

REACTOME

REACT_23946

Prostacyclin signalling through prostacyclin receptor pathway

REACT_23876

Platelet homeostasis pathway

REACT_20653

ADP signalling through P2Y purinoceptor 12 pathway

REACT_19140

ADP signalling through P2Y purinoceptor 1 pathway

REACT_20647

Thromboxane signalling through TP receptor pathway

REACT_21384

Thrombin signalling through proteinase activated receptors (PARs) pathway

REACT_24023

Vasopressin regulates renal water homeostasis via Aquaporins pathway

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_19231

G alpha (i) signalling events pathway

REACT_19290

G beta:gamma signalling through PI3Kgamma pathway

REACT_19145

G beta:gamma signalling through PLC beta pathway

REACT_18407

G alpha (12/13) signalling events pathway

REACT_19327

G alpha (s) signalling events pathway

REACT_19333

G alpha (z) signalling events pathway

REACT_18377

Glucagon-type ligand receptors pathway

REACT_18372

Class B/2 (Secretin family receptors) pathway

REACT_15457

G-protein activation pathway

REACT_15295

Opioid Signalling pathway

REACT_25004

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway

REACT_25031

GABA B receptor activation pathway

REACT_21254

Presynaptic function of Kainate receptors pathway

REACT_75831

Activation of G protein gated Potassium channels pathway

REACT_18274

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway

REACT_18339

Adrenaline,noradrenaline inhibits insulin secretion pathway

REACT_18325

Regulation of insulin secretion pathway

REACT_1665

Glucagon signaling in metabolic regulation pathway

REACT_1505

Integration of energy metabolism pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_172761

Ca2+ pathway pathway

REACT_172694

beta-catenin independent WNT signaling pathway

REACT_11045

Signaling by Wnt pathway

REACT_13685

Neuronal System pathway

REACT_14797

Signaling by GPCR pathway

REACT_25199

GABA receptor activation pathway

REACT_75780

G protein gated Potassium channels pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_19388

G-protein beta:gamma signalling pathway

REACT_25330

Activation of GABAB receptors pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_75918

Inwardly rectifying K+ channels pathway

REACT_21312

Activation of Kainate Receptors upon glutamate binding pathway

REACT_75908

Potassium Channels pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_21340

GPCR ligand binding pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_111217

Metabolism pathway

REACT_20524

Signal amplification pathway

REACT_23887

Aquaporin-mediated transport pathway

REACT_604

Hemostasis pathway

KEGG

hsa04062

Chemokine signaling pathway pathway

INOH

PID NCI

ar_nongenomic_pathway

Nongenotropic Androgen signaling

rapid_gr_pathway

Rapid glucocorticoid signaling

txa2pathway

Thromboxane A2 receptor signaling

il8cxcr2_pathway

IL8- and CXCR2-mediated signaling events

lysophospholipid_pathway

LPA receptor mediated events

cxcr4_pathway

CXCR4-mediated signaling events

il8cxcr1_pathway

IL8- and CXCR1-mediated signaling events

thrombin_par1_pathway

PAR1-mediated thrombin signaling events

hdac_classii_pathway

Signaling events mediated by HDAC Class II

er_nongenomic_pathway

Plasma membrane estrogen receptor signaling

thrombin_par4_pathway

PAR4-mediated thrombin signaling events

hedgehog_glipathway

Hedgehog signaling events mediated by Gli proteins

cxcr3pathway

CXCR3-mediated signaling events

Cross-References

SwissProt

P59768

TrEMBL

UniProt Splice Variant

Entrez Gene

54331

UniGene

Hs.187772 Hs.709082 Hs.720063 Hs.741081

RefSeq

NM_001243773 NM_001243774 NM_053064 XM_006720173

HUGO

HGNC:4404

OMIM

606981

CCDS

CCDS32082

HPRD

16234

IMGT

EMBL

AF493870 AL832878 BC020774 BC060856 CH471078

GenPept

AAH20774 AAH60856 AAM12584 CAI46198 EAW65663

RNA Seq Atlas

54331