Version 5.4
Homo sapiens Gene: SIGLEC8
Summary
InnateDB Gene IDBG-65955.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIGLEC8
Gene Name sialic acid binding Ig-like lectin 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105366
Encoded Proteins
IDBP-65957
sialic acid binding Ig-like lectin 8
IDBP-65959
sialic acid binding Ig-like lectin 8
IDBP-384103
sialic acid binding Ig-like lectin 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21208791
SIGLEC8 is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
Entrez Gene
Summary Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:51450847-51458456
Strand Reverse strand
Band q13.41
Transcripts
ENST00000321424 ENSP00000321077
ENST00000340550 ENSP00000339448
ENST00000430817 ENSP00000389142
ENST00000597352
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL C9JT30
UniProt Splice Variant
Entrez Gene 27181
UniGene Hs.447899
RefSeq NM_014442
HUGO HGNC:10877
OMIM 605639
CCDS CCDS33086
HPRD 16132
IMGT
EMBL AC020914
GenPept
RNA Seq Atlas 27181

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca