InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EXOSC3

Summary

InnateDB Gene

IDBG-66000.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EXOSC3

Gene Name

exosome component 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000107371

Encoded Proteins

IDBP-66002

exosome component 3

IDBP-237319

exosome component 3

IDBP-479331

exosome component 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a non-catalytic component of the human exosome, a complex with 3'-5' exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromosome 19 and 21. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:37766978-37801437

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000327304	ENSP00000323046
ENST00000396521	ENSP00000379775
ENST00000465229	ENSP00000418422
ENST00000490516
ENST00000489414
ENST00000482614
ENST00000465860
ENST00000496910

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.

Experimentally validated
Total	45 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000175	3'-5'-exoribonuclease activity
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006364	rRNA processing
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0045006	DNA deamination
GO:0045190	isotype switching
GO:0045830	positive regulation of isotype switching
GO:0071034	CUT catabolic process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0000176	nuclear exosome (RNase complex)
GO:0000177	cytoplasmic exosome (RNase complex)
GO:0000178	exosome (RNase complex)
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0035327	transcriptionally active chromatin