Homo sapiens Gene: BAMBI | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Gene | IDBG-66015.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | BAMBI | ||||||||||||||||||||
Gene Name | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) | ||||||||||||||||||||
Synonyms | NMA | ||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||
Ensembl Gene | ENSG00000095739 | ||||||||||||||||||||
Encoded Proteins |
BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
BMP and activin membrane-bound inhibitor
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Protein Structure | |||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
Summary |
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||
Genomic Location | Chromosome 10:28677342-28682939 | ||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||
Band | p12.1 | ||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME |
Downregulation of TGF-beta receptor signaling pathway
TGF-beta receptor signaling activates SMADs pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
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KEGG |
Wnt signaling pathway pathway
TGF-beta signaling pathway pathway
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INOH |
BMP2 signaling pathway
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PID NCI |
BMP receptor signaling
TGF-beta receptor signaling
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Cross-References | |||||||||||||||||||||
SwissProt | Q13145 | ||||||||||||||||||||
TrEMBL | |||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 25805 | ||||||||||||||||||||
UniGene | Hs.533336 Hs.703618 | ||||||||||||||||||||
RefSeq | NM_012342 | ||||||||||||||||||||
HUGO | HGNC:30251 | ||||||||||||||||||||
OMIM | 604444 | ||||||||||||||||||||
CCDS | CCDS7162 | ||||||||||||||||||||
HPRD | 05117 | ||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | AL161936 BC019252 BT006820 U23070 U29188 U29189 | ||||||||||||||||||||
GenPept | AAC50435 AAH19252 AAP35466 AAR02414 CAC16002 | ||||||||||||||||||||
RNA Seq Atlas | 25805 | ||||||||||||||||||||