Version 5.4
Homo sapiens Gene: PRMT2
Summary
InnateDB Gene IDBG-6604.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRMT2
Gene Name protein arginine methyltransferase 2
Synonyms HRMT1L1
Species Homo sapiens
Ensembl Gene ENSG00000160310
Encoded Proteins
IDBP-6606
protein arginine methyltransferase 2
IDBP-6608
protein arginine methyltransferase 2
IDBP-6612
protein arginine methyltransferase 2
IDBP-234912
protein arginine methyltransferase 2
IDBP-234914
protein arginine methyltransferase 2
IDBP-234918
protein arginine methyltransferase 2
IDBP-372029
protein arginine methyltransferase 2
IDBP-372038
protein arginine methyltransferase 2
IDBP-372043
protein arginine methyltransferase 2
IDBP-372050
protein arginine methyltransferase 2
IDBP-810562
protein arginine methyltransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 21:46635167-46665124
Strand Forward strand
Band q22.3
Transcripts
ENST00000355680 ENSP00000347906
ENST00000291705 ENSP00000291705
ENST00000334494 ENSP00000335490
ENST00000397638 ENSP00000380760
ENST00000397637 ENSP00000380759
ENST00000397628 ENSP00000380752
ENST00000458387 ENSP00000407463
ENST00000451211 ENSP00000411984
ENST00000440086 ENSP00000397266
ENST00000455177 ENSP00000406127
ENST00000482508
ENST00000481861
ENST00000491389
ENST00000498151
ENST00000486520
ENST00000621201 ENSP00000482158
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008469 histone-arginine N-methyltransferase activity
GO:0016274 protein-arginine N-methyltransferase activity
GO:0016740 transferase activity
GO:0030331 estrogen receptor binding
GO:0033142 progesterone receptor binding
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0042803 protein homodimerization activity
GO:0042974 retinoic acid receptor binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0046966 thyroid hormone receptor binding
GO:0050681 androgen receptor binding
Biological Process
GO:0006479 protein methylation
GO:0007165 signal transduction
GO:0016571 histone methylation
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034969 histone arginine methylation
GO:0043065 positive regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048588 developmental cell growth
GO:0060765 regulation of androgen receptor signaling pathway
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0035189 Rb-E2F complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020230
View Gene Order
ENSBTAG00000005503
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.154163 Hs.619529
RefSeq NM_001242864 NM_001242865 NM_001242866 NM_001286676 NM_001286677 NM_001286678 NM_001535 NM_206962 XM_005261111 XM_006723998 XM_006724000
HUGO
OMIM
CCDS CCDS13737 CCDS56219 CCDS56220 CCDS68230 CCDS68231 CCDS74806
HPRD 09060
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca