Version 5.4
Homo sapiens Gene: SHB
Summary
InnateDB Gene IDBG-66131.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHB
Gene Name Src homology 2 domain containing adaptor protein B
Synonyms bA3J10.2
Species Homo sapiens
Ensembl Gene ENSG00000107338
Encoded Proteins
IDBP-66133
Src homology 2 domain containing adaptor protein B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:37919134-38069211
Strand Reverse strand
Band p13.1
Transcripts
ENST00000377707 ENSP00000366936
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0009967 positive regulation of signal transduction
GO:0030154 cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044813
View Gene Order
ENSBTAG00000014922
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
NetPath_14
IL2 pathway
REACTOME
REACT_111045
Developmental Biology pathway
REACT_12529
Signaling by VEGF pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_228170
EPH-Ephrin signaling pathway
KEGG
INOH
PID NCI
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
pdgfrapathway
PDGFR-alpha signaling pathway
Cross-References
SwissProt Q15464
TrEMBL
UniProt Splice Variant
Entrez Gene 6461
UniGene Hs.521482
RefSeq NM_003028
HUGO HGNC:10838
OMIM 600314
CCDS CCDS43806
HPRD
IMGT
EMBL AL138752 AL161448 AL583849 BC094765 BC136581 BC136582 CH471071 X75342
GenPept AAH94765 AAI36582 AAI36583 CAA53091 CAH73120 CAH73192 CAI13876 EAW58254 EAW58255
RNA Seq Atlas 6461

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca