Version 5.4
| Homo sapiens Gene: SIGLEC5 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-66180.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | SIGLEC5 | ||||||||||||||||||
| Gene Name | sialic acid binding Ig-like lectin 5 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000105501 | ||||||||||||||||||
| Encoded Proteins | |||||||||||||||||||
| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
SIGLEC5 is bound by group B Streptococcus (GBS) beta protein and this functions to impair human leukocyte phagocytosis, oxidative burst, and extracellular trap production, promoting bacterial survival.
SIGLEC5 is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||
| Summary |
[Mus musculus] Siglec5 is a member of the rapidly evolving CD33-related siglec subfamily that are expressed on cells of the innate immune system. Siglec5 mediates endocytosis of anti-Siglec5 and sialoside ligands and Sigelc5 endocytosis is clathrin and dynamin independent, requires ADP ribosylation factor 6, and traffics to lysosomes.
[Mus musculus] Siglec5 is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
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| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 19:51611503-51645545 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q13.41 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
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Gene ID
Gene Order
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| Cross-References | |||||||||||||||||||
| SwissProt | O15389 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 8778 | ||||||||||||||||||
| UniGene | Hs.310333 Hs.628360 | ||||||||||||||||||
| RefSeq | NM_003830 | ||||||||||||||||||
| HUGO | HGNC:10874 | ||||||||||||||||||
| OMIM | 604200 | ||||||||||||||||||
| CCDS | CCDS33088 | ||||||||||||||||||
| HPRD | 05011 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC018755 AF170484 BC029896 U71383 | ||||||||||||||||||
| GenPept | AAB70703 AAD50978 AAF87846 AAH29896 | ||||||||||||||||||
| RNA Seq Atlas | 8778 | ||||||||||||||||||