Version 5.4
Homo sapiens Gene: POLR1B
Summary
InnateDB Gene IDBG-66306.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR1B
Gene Name polymerase (RNA) I polypeptide B, 128kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000125630
Encoded Proteins
IDBP-66308
polymerase (RNA) I polypeptide B, 128kDa
IDBP-66310
polymerase (RNA) I polypeptide B, 128kDa
IDBP-294798
polymerase (RNA) I polypeptide B, 128kDa
IDBP-384779
polymerase (RNA) I polypeptide B, 128kDa
IDBP-384780
polymerase (RNA) I polypeptide B, 128kDa
IDBP-384782
polymerase (RNA) I polypeptide B, 128kDa
IDBP-384783
polymerase (RNA) I polypeptide B, 128kDa
IDBP-384784
polymerase (RNA) I polypeptide B, 128kDa
IDBP-384787
polymerase (RNA) I polypeptide B, 128kDa
IDBP-384788
polymerase (RNA) I polypeptide B, 128kDa
IDBP-591088
polymerase (RNA) I polypeptide B, 128kDa
IDBP-603520
polymerase (RNA) I polypeptide B, 128kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:112541915-112577150
Strand Forward strand
Band q14.1
Transcripts
ENST00000263331 ENSP00000263331
ENST00000333990 ENSP00000334589
ENST00000409894 ENSP00000387143
ENST00000438748 ENSP00000388577
ENST00000430769 ENSP00000415754
ENST00000448770 ENSP00000390274
ENST00000430293 ENSP00000403094
ENST00000424062 ENSP00000390973
ENST00000417433 ENSP00000405358
ENST00000458012 ENSP00000394408
ENST00000496238
ENST00000468475
ENST00000475318
ENST00000498054
ENST00000484574
ENST00000541869 ENSP00000444136
ENST00000537335 ENSP00000437914
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0005515 protein binding
GO:0032549 ribonucleoside binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006362 transcription elongation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0007566 embryo implantation
GO:0009303 rRNA transcription
GO:0010467 gene expression
GO:0017126 nucleologenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005736 DNA-directed RNA polymerase I complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027395
View Gene Order
ENSBTAG00000014166
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_1074
RNA Polymerase I Transcription Termination pathway
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_1913
RNA Polymerase I Promoter Escape pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
hsa03020
RNA polymerase pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.619285
RefSeq NM_001137604 NM_001282772 NM_001282774 NM_001282776 NM_001282777 NM_001282779 NM_019014
HUGO
OMIM
CCDS CCDS2097 CCDS46395 CCDS62988 CCDS62989 CCDS62990
HPRD 06852
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca