Version 5.4
Homo sapiens Gene: CARD10
Summary
InnateDB Gene IDBG-6632.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CARD10
Gene Name caspase recruitment domain family, member 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100065
Encoded Proteins
IDBP-6634
caspase recruitment domain family, member 10
IDBP-293846
caspase recruitment domain family, member 10
IDBP-293842
caspase recruitment domain family, member 10
IDBP-375429
caspase recruitment domain family, member 10
IDBP-375431
caspase recruitment domain family, member 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:37490362-37519542
Strand Reverse strand
Band q13.1
Transcripts
ENST00000251973 ENSP00000251973
ENST00000403299 ENSP00000384570
ENST00000406271 ENSP00000385799
ENST00000437756 ENSP00000416239
ENST00000433485 ENSP00000393411
ENST00000488141
ENST00000467812
ENST00000486118
ENST00000476871
ENST00000494166
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030159 receptor signaling complex scaffold activity
Biological Process
GO:0006461 protein complex assembly
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0042981 regulation of apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0032449 CBM complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033170
View Gene Order
ENSBTAG00000015044
Not yet available
Cross-References
SwissProt
TrEMBL B0QYC4
UniProt Splice Variant
Entrez Gene 29775
UniGene Hs.57973 Hs.739716
RefSeq NM_014550
HUGO HGNC:16422
OMIM 607209
CCDS CCDS13948
HPRD 06233
IMGT
EMBL AL022315 AL049851
GenPept
RNA Seq Atlas 29775

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca