Version 5.4
Homo sapiens Gene: CCDC39
Summary
InnateDB Gene IDBG-66592.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCDC39
Gene Name coiled-coil domain containing 39
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000145075
Encoded Proteins
IDBP-385680
coiled-coil domain containing 39
IDBP-475492
coiled-coil domain containing 39
IDBP-484512
coiled-coil domain containing 39
IDBP-474455
coiled-coil domain containing 39
IDBP-476870
coiled-coil domain containing 39
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is involved in the motility of cilia and flagella. The encoded protein is essential for the assembly of dynein regulatory and inner dynein arm complexes, which regulate ciliary beat. Defects in this gene are a cause of primary ciliary dyskinesia type 14 (CILD14). [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:180602858-180871005
Strand Reverse strand
Band q26.33
Transcripts
ENST00000442201 ENSP00000405708
ENST00000473854 ENSP00000418482
ENST00000489868 ENSP00000420025
ENST00000476379 ENSP00000417960
ENST00000471307 ENSP00000418702
ENST00000485055
ENST00000495817
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
Biological Process
GO:0001947 heart looping
GO:0030324 lung development
GO:0035469 determination of pancreatic left/right asymmetry
GO:0060285 cilium-dependent cell motility
GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry
GO:0070286 axonemal dynein complex assembly
GO:0071907 determination of digestive tract left/right asymmetry
GO:0071910 determination of liver left/right asymmetry
Cellular Component
GO:0005856 cytoskeleton
GO:0005930 axoneme
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027676
View Gene Order
ENSBTAG00000001969
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.712820 Hs.734332 Hs.734668
RefSeq NM_181426
HUGO
OMIM
CCDS CCDS46964
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca