Version 5.4
Homo sapiens Gene: CDC42EP4
Summary
InnateDB Gene IDBG-66850.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC42EP4
Gene Name CDC42 effector protein (Rho GTPase binding) 4
Synonyms BORG4; CEP4; KAIA1777
Species Homo sapiens
Ensembl Gene ENSG00000179604
Encoded Proteins
IDBP-66852
CDC42 effector protein (Rho GTPase binding) 4
IDBP-383913
CDC42 effector protein (Rho GTPase binding) 4
IDBP-762738
IDBP-760071
IDBP-758109
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:73283624-73312175
Strand Reverse strand
Band q25.1
Transcripts
ENST00000335793 ENSP00000338258
ENST00000439510 ENSP00000404270
ENST00000581045
ENST00000581014 ENSP00000464104
ENST00000578516
ENST00000579611 ENSP00000463877
ENST00000580315 ENSP00000462231
ENST00000582303
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017049 GTP-Rho binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007266 Rho protein signal transduction
GO:0008360 regulation of cell shape
GO:0031274 positive regulation of pseudopodium assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041598
View Gene Order
ENSBTAG00000019115
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.3903
RefSeq NM_012121 XM_005257182
HUGO
OMIM
CCDS CCDS11695
HPRD 08383
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca