Version 5.4
Homo sapiens Gene: AKAP4
Summary
InnateDB Gene IDBG-66994.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKAP4
Gene Name A kinase (PRKA) anchor protein 4
Synonyms AKAP 82; AKAP-4; AKAP82; CT99; FSC1; hAKAP82; HI; p82; PRKA4
Species Homo sapiens
Ensembl Gene ENSG00000147081
Encoded Proteins
IDBP-66996
A kinase (PRKA) anchor protein 4
IDBP-66998
A kinase (PRKA) anchor protein 4
IDBP-372164
A kinase (PRKA) anchor protein 4
IDBP-372166
A kinase (PRKA) anchor protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:50190768-50201013
Strand Reverse strand
Band p11.22
Transcripts
ENST00000358526 ENSP00000351327
ENST00000376064 ENSP00000365232
ENST00000448865 ENSP00000402403
ENST00000437370 ENSP00000412279
ENST00000481402
ENST00000480926
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051018 protein kinase A binding
Biological Process
GO:0006928 cellular component movement
GO:0007165 signal transduction
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007338 single fertilization
GO:0008104 protein localization
GO:0030030 cell projection organization
GO:0030317 sperm motility
Cellular Component
GO:0005634 nucleus
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0005952 cAMP-dependent protein kinase complex
GO:0030018 Z disc
GO:0031514 motile cilium
GO:0035686 sperm fibrous sheath
GO:0048471 perinuclear region of cytoplasm
GO:0097228 sperm principal piece
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050089
View Gene Order
ENSBTAG00000016399
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 8852
UniGene Hs.97633
RefSeq NM_003886 NM_139289
HUGO HGNC:374
OMIM 300185
CCDS CCDS14329 CCDS14330
HPRD 02173
IMGT
EMBL
GenPept
RNA Seq Atlas 8852

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca