Version 5.4
Homo sapiens Gene: ARHGAP12
Summary
InnateDB Gene IDBG-67225.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP12
Gene Name Rho GTPase activating protein 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165322
Encoded Proteins
IDBP-67227
Rho GTPase activating protein 12
IDBP-67229
Rho GTPase activating protein 12
IDBP-67231
Rho GTPase activating protein 12
IDBP-67233
Rho GTPase activating protein 12
IDBP-238088
Rho GTPase activating protein 12
IDBP-371999
Rho GTPase activating protein 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:31805404-31928876
Strand Reverse strand
Band p11.22
Transcripts
ENST00000375250 ENSP00000364399
ENST00000311380 ENSP00000310984
ENST00000344936 ENSP00000345808
ENST00000375245 ENSP00000364394
ENST00000396144 ENSP00000379448
ENST00000454919 ENSP00000398050
ENST00000492028
ENST00000497085
ENST00000493008
ENST00000497103
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0002011 morphogenesis of an epithelial sheet
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041225
View Gene Order
ENSBTAG00000012677
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8IWW6
TrEMBL D3DRX4 Q1RLN5
UniProt Splice Variant
Entrez Gene 94134
UniGene Hs.499264 Hs.741991
RefSeq NM_001270697 NM_001270695 NM_001270696 NM_001270698 NM_001270699 NM_018287 XM_005252644 XM_006717540
HUGO HGNC:16348
OMIM 610577
CCDS CCDS73082 CCDS59214 CCDS59215 CCDS59216 CCDS7170
HPRD 06446
IMGT
EMBL AL137485 AL390715 AL834250 AY033594 AY033595 BC051811 BC094719 BC115362 BC115363 CH471072
GenPept AAH51811 AAH94719 AAI15363 AAI15364 AAK52311 AAK52312 CAB70766 CAD38926 CAI12371 CAI12372 CAI12373 EAW85980 EAW85981 EAW85982 EAW85983 EAW85984 EAW85985
RNA Seq Atlas 94134

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca