InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ACTR3

Summary

InnateDB Gene

IDBG-67369.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTR3

Gene Name

ARP3 actin-related protein 3 homolog (yeast)

Synonyms

ARP3

Species

Homo sapiens

Ensembl Gene

ENSG00000115091

Encoded Proteins

IDBP-67371

ARP3 actin-related protein 3 homolog (yeast)

IDBP-385058

ARP3 actin-related protein 3 homolog (yeast)

IDBP-385059

ARP3 actin-related protein 3 homolog (yeast)

IDBP-385061

ARP3 actin-related protein 3 homolog (yeast)

IDBP-601924

ARP3 actin-related protein 3 homolog (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:113889960-113962596

Strand

Forward strand

Band

q14.1

Transcripts

ENST00000263238	ENSP00000263238
ENST00000443297	ENSP00000403125
ENST00000415792	ENSP00000407912
ENST00000446821	ENSP00000394213
ENST00000489779
ENST00000484165
ENST00000478928
ENST00000535589	ENSP00000444987

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	68 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0006928	cellular component movement
GO:0007163	establishment or maintenance of cell polarity
GO:0008356	asymmetric cell division
GO:0009743	response to carbohydrate
GO:0010592	positive regulation of lamellipodium assembly
GO:0016344	meiotic chromosome movement towards spindle pole
GO:0030838	positive regulation of actin filament polymerization
GO:0033206	cytokinesis after meiosis
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043519	regulation of myosin II filament organization
GO:0045087	innate immune response
GO:0045666	positive regulation of neuron differentiation
GO:0046677	response to antibiotic
GO:0050775	positive regulation of dendrite morphogenesis
GO:0051321	meiotic cell cycle
GO:0051491	positive regulation of filopodium assembly
GO:0051653	spindle localization
GO:0060271	cilium morphogenesis

Cellular Component

GO:0000139	Golgi membrane
GO:0002102	podosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005884	actin filament
GO:0005885	Arp2/3 protein complex
GO:0005911	cell-cell junction
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030056	hemidesmosome
GO:0031252	cell leading edge
GO:0060076	excitatory synapse
GO:0070062	extracellular vesicular exosome