InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EIF2B5

Summary

InnateDB Gene

IDBG-67399.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF2B5

Gene Name

eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa

Synonyms

CACH; CLE; EIF-2B; EIF2Bepsilon; LVWM

Species

Homo sapiens

Ensembl Gene

ENSG00000145191

Encoded Proteins

IDBP-67401

eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa

IDBP-385857

eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa

IDBP-385858

eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa

IDBP-385859

eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:184135038-184684758

Strand

Forward strand

Band

q27.1

Transcripts

ENST00000273783	ENSP00000273783
ENST00000432569	ENSP00000414775
ENST00000444495	ENSP00000409142
ENST00000432982	ENSP00000408198
ENST00000491144
ENST00000481054
ENST00000471832
ENST00000498831
ENST00000491008
ENST00000468748
ENST00000479833
ENST00000493740
ENST00000492773
ENST00000479250
ENST00000465218
ENST00000484154
ENST00000492226

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0031369	translation initiation factor binding

Biological Process

GO:0001541	ovarian follicle development
GO:0006412	translation
GO:0006413	translational initiation
GO:0006417	regulation of translation
GO:0009408	response to heat
GO:0009749	response to glucose
GO:0010467	gene expression
GO:0014002	astrocyte development
GO:0014003	oligodendrocyte development
GO:0032057	negative regulation of translational initiation in response to stress
GO:0034976	response to endoplasmic reticulum stress
GO:0035690	cellular response to drug
GO:0042552	myelination
GO:0043434	response to peptide hormone
GO:0043547	positive regulation of GTPase activity
GO:0044267	cellular protein metabolic process
GO:0045948	positive regulation of translational initiation
GO:0048708	astrocyte differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005851	eukaryotic translation initiation factor 2B complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000003235

View Gene Order

ENSBTAG00000011414

Not yet available

Pathways

NETPATH

REACTOME

REACT_1815

Recycling of eIF2:GDP pathway

REACT_2159

Eukaryotic Translation Initiation pathway

REACT_1014

Translation pathway

REACT_17015

Metabolism of proteins pathway

REACT_2099

Cap-dependent Translation Initiation pathway

REACT_71

Gene Expression pathway

KEGG

hsa03013

RNA transport pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.283551 Hs.608550

RefSeq

NM_003907

HUGO

OMIM

CCDS

CCDS3252

HPRD

04898

IMGT

EMBL

GenPept

RNA Seq Atlas