InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DVL3

Summary

InnateDB Gene

IDBG-67447.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DVL3

Gene Name

dishevelled, dsh homolog 3 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000161202

Encoded Proteins

IDBP-67449

dishevelled, dsh homolog 3 (Drosophila)

IDBP-385866

dishevelled, dsh homolog 3 (Drosophila)

IDBP-385870

dishevelled, dsh homolog 3 (Drosophila)

IDBP-385872

dishevelled, dsh homolog 3 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:184155388-184173610

Strand

Forward strand

Band

q27.1

Transcripts

ENST00000313143	ENSP00000316054
ENST00000435708	ENSP00000412345
ENST00000431765	ENSP00000405885
ENST00000423300	ENSP00000393849
ENST00000462665
ENST00000478247
ENST00000467873
ENST00000478639

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	60 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004871	signal transducer activity
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0003007	heart morphogenesis
GO:0003148	outflow tract septum morphogenesis
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0016055	Wnt signaling pathway
GO:0035556	intracellular signal transduction
GO:0035567	non-canonical Wnt signaling pathway
GO:0038031	non-canonical Wnt signaling pathway via JNK cascade
GO:0042493	response to drug
GO:0043507	positive regulation of JUN kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060026	convergent extension
GO:0060070	canonical Wnt signaling pathway
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0090103	cochlea morphogenesis
GO:0090179	planar cell polarity pathway involved in neural tube closure